Cargando…

The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders

Altered glutamate transporter expression is a common feature of many neuropsychiatric conditions, including schizophrenia. Excitatory amino acid transporters (EAATs) are responsible for the reuptake of glutamate, preventing non-physiological spillover from the synapse. Postmortem studies have reveal...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Donovan, Sinead M., Sullivan, Courtney R., McCullumsmith, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608761/ https://www.ncbi.nlm.nih.gov/pubmed/28935880 http://dx.doi.org/10.1038/s41537-017-0037-1

Ejemplares similares

Strategies to identify candidate repurposable drugs: COVID-19 treatment as a case example
por: Imami, Ali S., et al.
Publicado: (2021)

Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia
por: O'Donovan, S M, et al.
Publicado: (2015)

12.2 METABOLIC CONSEQUENCES OF DEVELOPMENTAL NMDA RECEPTOR HYPOFUNCTION
por: Funk, Adam, et al.
Publicado: (2018)

Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia
por: Sullivan, Courtney R., et al.
Publicado: (2018)

12.1 CELL-SUBTYPE SPECIFIC BIOENERGETIC DEFECTS IN SCHIZOPHRENIA
por: Sullivan, Courtney, et al.
Publicado: (2018)

Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment?
por: Hamoud, Abdul-Rizaq, et al.
Publicado: (2022)

The genetics of neuropsychiatric disorders
por: Bray, Nicholas J., et al.
Publicado: (2018)

Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia
por: Sullivan, Courtney R., et al.
Publicado: (2019)

Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection
por: Creeden, Justin Fortune, et al.
Publicado: (2021)

The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
por: Anand, Nikhilesh, et al.
Publicado: (2022)

Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets
por: Zhang, Xiaolu, et al.
Publicado: (2022)

Altered purinergic receptor expression in the frontal cortex in schizophrenia
por: Alnafisah, Rawan, et al.
Publicado: (2022)

Decreased Chloride Channel Expression in the Dorsolateral Prefrontal Cortex in Schizophrenia
por: Sullivan, Courtney R., et al.
Publicado: (2015)

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter
por: Bentea, Eduard, et al.
Publicado: (2020)

Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation
por: Lin, Boren, et al.
Publicado: (2021)

S183. ABNORMALITIES IN SERINE/THREONINE SIGNALING NETWORKS IN SEVERE NEUROPSYCHIATRIC ILLNESS: DEVELOPMENT OF A PIPELINE TO EXPLORE ABNORMALITIES OF KINASE ACTIVITY AND IDENTIFY NOVEL TREATMENT STRATEGIES FOR SCHIZOPHRENIA
por: McCullumsmith, Robert, et al.
Publicado: (2020)

The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders
por: Baskerville, Richard, et al.
Publicado: (2023)

Editorial: Glutamate-Related Biomarkers for Neuropsychiatric Disorders
por: Lin, Chieh-Hsin, et al.
Publicado: (2019)

Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders
por: Parkin, Georgia M, et al.
Publicado: (2018)

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic Considerations
por: Muneer, Ather
Publicado: (2020)

Using protein turnover to expand the applications of transcriptomics
por: Smail, Marissa A., et al.
Publicado: (2021)

32.2 ABNORMALITIES OF SYNAPTIC PROTEOMES IN SCHIZOPHRENIA
por: Funk, Adam, et al.
Publicado: (2018)

Genetics and epigenetics as tools to inform the pathophysiology of neuropsychiatric disorders
por: Fries, Gabriel Rodrigo
Publicado: (2019)

Transdiagnostic Role of Glutamate and White Matter Damage in Neuropsychiatric Disorders: A Systematic Review
por: Luttenbacher, I., et al.
Publicado: (2022)

Identification of new drug treatments to combat COVID19: A signature-based approach using iLINCS
por: O’Donovan, Sinead M, et al.
Publicado: (2020)

Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders
por: Nakazawa, Takanobu, et al.
Publicado: (2016)

Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach
por: O’Donovan, Sinead M., et al.
Publicado: (2021)

A review of pathophysiology and neuropsychiatric manifestations of COVID-19
por: Jasti, Madhu, et al.
Publicado: (2020)

F201. KINASE NETWORK DYSREGULATION IN SCHIZOPHRENIA: IMPLICATIONS FOR NEW TREATMENT STRATEGIES
por: Bentea, Eduard, et al.
Publicado: (2018)

Similarities and dissimilarities between psychiatric cluster disorders
por: Smail, Marissa A., et al.
Publicado: (2021)

SSRIs: Applications in inflammatory lung disease and implications for COVID‐19
por: Meikle, Claire Kyung Sun, et al.
Publicado: (2021)

The Role of Tryptophan Metabolites in Neuropsychiatric Disorders
por: Davidson, Majid, et al.
Publicado: (2022)

The role of maternal obesity in the risk of neuropsychiatric disorders
por: Rivera, Heidi M., et al.
Publicado: (2015)

The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related Disorders
por: Peterlik, Daniel, et al.
Publicado: (2016)

Pathophysiology and Clinical Features of Neuropsychiatric Manifestations of Thyroid Disease
por: Jurado-Flores, Marilu, et al.
Publicado: (2022)

Ampa Receptor Subunit Expression in the Endoplasmic Reticulum in Frontal Cortex of Elderly Patients with Schizophrenia
por: Hammond, John C., et al.
Publicado: (2012)

Disclosing the potential impact of placebo controls in antidepressant trials
por: Chen, Stephanie C., et al.
Publicado: (2015)

Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression
por: Rice, Frances, et al.
Publicado: (2018)

Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders
por: Nakazawa, Takanobu, et al.
Publicado: (2016)

The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease
por: Lee, Jung Goo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tj97lp94d7390om0vls8i6urk8