Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have somatic inactivating mutations in the BAP1 gene. BAP1 is a homologous recombination (HR) DNA...

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Detalles Bibliográficos
Autores principales: Srinivasan, Gayathri, Sidhu, Gurjit Singh, Williamson, Elizabeth A., Jaiswal, Aruna S., Najmunnisa, Nasreen, Wilcoxen, Keith, Jones, Dennie, George, Thomas J., Hromas, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608777/
https://www.ncbi.nlm.nih.gov/pubmed/28756516
http://dx.doi.org/10.1007/s00280-017-3401-y

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