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Mucin 5B in saliva and serum of patients with oral lichen planus

Oral lichen planus (OLP) is among the most common oral diseases. Its etiopathogenesis has yet to be clearly identified. OLP patients complain of mouth dryness. This study aimed to assess the level of Mucin 5B in OLP patients with xerostomia. This study was conducted on 30 OLP patients and 30 healthy...

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Autores principales: Agha-Hosseini, Farzaneh, Imanpour, Mojtaba, Mirzaii-Dizgah, Iraj, Moosavi, Mahdieh-Sadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608939/
https://www.ncbi.nlm.nih.gov/pubmed/28935947
http://dx.doi.org/10.1038/s41598-017-12157-1
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author Agha-Hosseini, Farzaneh
Imanpour, Mojtaba
Mirzaii-Dizgah, Iraj
Moosavi, Mahdieh-Sadat
author_facet Agha-Hosseini, Farzaneh
Imanpour, Mojtaba
Mirzaii-Dizgah, Iraj
Moosavi, Mahdieh-Sadat
author_sort Agha-Hosseini, Farzaneh
collection PubMed
description Oral lichen planus (OLP) is among the most common oral diseases. Its etiopathogenesis has yet to be clearly identified. OLP patients complain of mouth dryness. This study aimed to assess the level of Mucin 5B in OLP patients with xerostomia. This study was conducted on 30 OLP patients and 30 healthy individuals. In addition to patient complaint of mouth dryness, xerostomia was assessed by tongue blade and lipstick tests. Stimulated and unstimulated saliva were collected in plastic vials by spitting method. Level of Mucin 5B was measured by ELISA. Unstimulated saliva flow was significantly lower in OLP patients (P = 0.0001). Stimulated saliva flow was not significantly different between the two groups (P > 0.05). Level of Mucin 5B in unstimulated saliva was significantly lower in OLP group (P = 0.0001) while it was not significantly different in stimulated saliva of the two groups (P > 0.05). Level of Mucin 5B was significantly higher in serum of OLP patients (P = 0.016). Both saliva flow and level of Mucin 5B decrease in OLP patients. Since Mucin 5B is effective for wetting and lubrication of the oral cavity, this result can suggest a possible reason for mouth dryness in OLP patients.
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spelling pubmed-56089392017-10-10 Mucin 5B in saliva and serum of patients with oral lichen planus Agha-Hosseini, Farzaneh Imanpour, Mojtaba Mirzaii-Dizgah, Iraj Moosavi, Mahdieh-Sadat Sci Rep Article Oral lichen planus (OLP) is among the most common oral diseases. Its etiopathogenesis has yet to be clearly identified. OLP patients complain of mouth dryness. This study aimed to assess the level of Mucin 5B in OLP patients with xerostomia. This study was conducted on 30 OLP patients and 30 healthy individuals. In addition to patient complaint of mouth dryness, xerostomia was assessed by tongue blade and lipstick tests. Stimulated and unstimulated saliva were collected in plastic vials by spitting method. Level of Mucin 5B was measured by ELISA. Unstimulated saliva flow was significantly lower in OLP patients (P = 0.0001). Stimulated saliva flow was not significantly different between the two groups (P > 0.05). Level of Mucin 5B in unstimulated saliva was significantly lower in OLP group (P = 0.0001) while it was not significantly different in stimulated saliva of the two groups (P > 0.05). Level of Mucin 5B was significantly higher in serum of OLP patients (P = 0.016). Both saliva flow and level of Mucin 5B decrease in OLP patients. Since Mucin 5B is effective for wetting and lubrication of the oral cavity, this result can suggest a possible reason for mouth dryness in OLP patients. Nature Publishing Group UK 2017-09-21 /pmc/articles/PMC5608939/ /pubmed/28935947 http://dx.doi.org/10.1038/s41598-017-12157-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Agha-Hosseini, Farzaneh
Imanpour, Mojtaba
Mirzaii-Dizgah, Iraj
Moosavi, Mahdieh-Sadat
Mucin 5B in saliva and serum of patients with oral lichen planus
title Mucin 5B in saliva and serum of patients with oral lichen planus
title_full Mucin 5B in saliva and serum of patients with oral lichen planus
title_fullStr Mucin 5B in saliva and serum of patients with oral lichen planus
title_full_unstemmed Mucin 5B in saliva and serum of patients with oral lichen planus
title_short Mucin 5B in saliva and serum of patients with oral lichen planus
title_sort mucin 5b in saliva and serum of patients with oral lichen planus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608939/
https://www.ncbi.nlm.nih.gov/pubmed/28935947
http://dx.doi.org/10.1038/s41598-017-12157-1
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