The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients fro...

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Detalles Bibliográficos
Autores principales: Kiaco, Kinanga, Rodrigues, António Sebastião, do Rosário, Virgílio, Gil, José Pedro, Lopes, Dinora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609073/
https://www.ncbi.nlm.nih.gov/pubmed/28934955
http://dx.doi.org/10.1186/s12936-017-2006-6
Descripción
Sumario:Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.

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