The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients fro...

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Autores principales: Kiaco, Kinanga, Rodrigues, António Sebastião, do Rosário, Virgílio, Gil, José Pedro, Lopes, Dinora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609073/
https://www.ncbi.nlm.nih.gov/pubmed/28934955
http://dx.doi.org/10.1186/s12936-017-2006-6
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author Kiaco, Kinanga
Rodrigues, António Sebastião
do Rosário, Virgílio
Gil, José Pedro
Lopes, Dinora
author_facet Kiaco, Kinanga
Rodrigues, António Sebastião
do Rosário, Virgílio
Gil, José Pedro
Lopes, Dinora
author_sort Kiaco, Kinanga
collection PubMed
description Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.
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spelling pubmed-56090732017-09-25 The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome Kiaco, Kinanga Rodrigues, António Sebastião do Rosário, Virgílio Gil, José Pedro Lopes, Dinora Malar J Case Report Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance. BioMed Central 2017-09-21 /pmc/articles/PMC5609073/ /pubmed/28934955 http://dx.doi.org/10.1186/s12936-017-2006-6 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kiaco, Kinanga
Rodrigues, António Sebastião
do Rosário, Virgílio
Gil, José Pedro
Lopes, Dinora
The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_full The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_fullStr The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_full_unstemmed The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_short The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_sort drug transporter abcb1 c.3435c>t snp influences artemether–lumefantrine treatment outcome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609073/
https://www.ncbi.nlm.nih.gov/pubmed/28934955
http://dx.doi.org/10.1186/s12936-017-2006-6
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