Cargando…

Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment

The most effective strategy to assess changes in the brain haemodynamics of stent angioplasty in patients with symptomatic ischemia of the M1 segment of the middle cerebral artery (MCA) remains unknown. The purpose of the present study was to use perfusion-weighted magnetic resonance imaging (PWI) t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ran, Yun-Cai, Zhu, Ming, Zhang, Yong, Li, Teng-Fei, Cheng, Jing-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609125/
https://www.ncbi.nlm.nih.gov/pubmed/28962101
http://dx.doi.org/10.3892/etm.2017.4747
_version_ 1783265556337524736
author Ran, Yun-Cai
Zhu, Ming
Zhang, Yong
Li, Teng-Fei
Cheng, Jing-Liang
author_facet Ran, Yun-Cai
Zhu, Ming
Zhang, Yong
Li, Teng-Fei
Cheng, Jing-Liang
author_sort Ran, Yun-Cai
collection PubMed
description The most effective strategy to assess changes in the brain haemodynamics of stent angioplasty in patients with symptomatic ischemia of the M1 segment of the middle cerebral artery (MCA) remains unknown. The purpose of the present study was to use perfusion-weighted magnetic resonance imaging (PWI) to evaluate the effect of stent angioplasty in treating patients with symptomatic MCA plaque stenosis. Stent angioplasty was performed on 23 patients with reduplicative transient ischaemic attack who were refractory to medical therapy. All patients had MCA plaque stenosis at the M1 segment. Brain PWI was obtained from four major regions of interest (ROIs) at the frontal parietal, temporal, lateral ventricle and basal ganglia lobes prior to and following stent implantation. In addition, cerebral blood flow (CBF), cerebral blood volume, mean transit time (MTT) and time to peak (TTP) parameters derived from PWI were calculated. All patients underwent digital subtraction angiography following surgery to confirm the patency. Computed tomography angiography or PWI was performed 1 week and 3 months post-surgery. According to pre-operative PWI, there was significant hypoperfusion in the symptomatic frontal parietal, temporal, lateral ventricle and basal ganglia lobes. By contrast, the regional CBF and CBF increased in the ROIs of the affected cerebral hemisphere 3 months after stent implantation (P<0.05 vs. pre-operative data). Additionally, post-operative MTT and TTP in the ROIs on the operative side were significantly shorter than pre-operative MTT and TTP (P<0.05). During the follow-up period, the frequency of transient ischaemic attack was reduced or disappeared in all patients during the follow-up. In conclusion, PWI enables an effective and objective assessment of haemodynamics prior to and following stent angioplasty in patients with plaque stenosis of MCA at the M1 segment.
format Online
Article
Text
id pubmed-5609125
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-56091252017-09-28 Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment Ran, Yun-Cai Zhu, Ming Zhang, Yong Li, Teng-Fei Cheng, Jing-Liang Exp Ther Med Articles The most effective strategy to assess changes in the brain haemodynamics of stent angioplasty in patients with symptomatic ischemia of the M1 segment of the middle cerebral artery (MCA) remains unknown. The purpose of the present study was to use perfusion-weighted magnetic resonance imaging (PWI) to evaluate the effect of stent angioplasty in treating patients with symptomatic MCA plaque stenosis. Stent angioplasty was performed on 23 patients with reduplicative transient ischaemic attack who were refractory to medical therapy. All patients had MCA plaque stenosis at the M1 segment. Brain PWI was obtained from four major regions of interest (ROIs) at the frontal parietal, temporal, lateral ventricle and basal ganglia lobes prior to and following stent implantation. In addition, cerebral blood flow (CBF), cerebral blood volume, mean transit time (MTT) and time to peak (TTP) parameters derived from PWI were calculated. All patients underwent digital subtraction angiography following surgery to confirm the patency. Computed tomography angiography or PWI was performed 1 week and 3 months post-surgery. According to pre-operative PWI, there was significant hypoperfusion in the symptomatic frontal parietal, temporal, lateral ventricle and basal ganglia lobes. By contrast, the regional CBF and CBF increased in the ROIs of the affected cerebral hemisphere 3 months after stent implantation (P<0.05 vs. pre-operative data). Additionally, post-operative MTT and TTP in the ROIs on the operative side were significantly shorter than pre-operative MTT and TTP (P<0.05). During the follow-up period, the frequency of transient ischaemic attack was reduced or disappeared in all patients during the follow-up. In conclusion, PWI enables an effective and objective assessment of haemodynamics prior to and following stent angioplasty in patients with plaque stenosis of MCA at the M1 segment. D.A. Spandidos 2017-09 2017-07-09 /pmc/articles/PMC5609125/ /pubmed/28962101 http://dx.doi.org/10.3892/etm.2017.4747 Text en Copyright: © Ran et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Ran, Yun-Cai
Zhu, Ming
Zhang, Yong
Li, Teng-Fei
Cheng, Jing-Liang
Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment
title Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment
title_full Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment
title_fullStr Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment
title_full_unstemmed Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment
title_short Perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the M1 segment
title_sort perfusion-weighted magnetic resonance imaging in the assessment of haemodynamics following stent angioplasty in patients with symptomatic middle cerebral artery plaque stenosis at the m1 segment
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609125/
https://www.ncbi.nlm.nih.gov/pubmed/28962101
http://dx.doi.org/10.3892/etm.2017.4747
work_keys_str_mv AT ranyuncai perfusionweightedmagneticresonanceimagingintheassessmentofhaemodynamicsfollowingstentangioplastyinpatientswithsymptomaticmiddlecerebralarteryplaquestenosisatthem1segment
AT zhuming perfusionweightedmagneticresonanceimagingintheassessmentofhaemodynamicsfollowingstentangioplastyinpatientswithsymptomaticmiddlecerebralarteryplaquestenosisatthem1segment
AT zhangyong perfusionweightedmagneticresonanceimagingintheassessmentofhaemodynamicsfollowingstentangioplastyinpatientswithsymptomaticmiddlecerebralarteryplaquestenosisatthem1segment
AT litengfei perfusionweightedmagneticresonanceimagingintheassessmentofhaemodynamicsfollowingstentangioplastyinpatientswithsymptomaticmiddlecerebralarteryplaquestenosisatthem1segment
AT chengjingliang perfusionweightedmagneticresonanceimagingintheassessmentofhaemodynamicsfollowingstentangioplastyinpatientswithsymptomaticmiddlecerebralarteryplaquestenosisatthem1segment