Cargando…

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

[Image: see text] Retinoid X receptors (RXRs) play key roles in many physiological processes in both the periphery and central nervous system. In addition, RXRs form heterodimers with other nuclear receptors to exert their physiological effects. The nuclear receptor related 1 protein (NURR1) is part...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scheepstra, Marcel, Andrei, Sebastian A., de Vries, Rens M. J. M., Meijer, Femke A., Ma, Jian-Nong, Burstein, Ethan S., Olsson, Roger, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609127/ https://www.ncbi.nlm.nih.gov/pubmed/28691794 http://dx.doi.org/10.1021/acschemneuro.7b00216

Ejemplares similares

Analysis of RXR/THR and RXR/PPARG2 Heterodimerization by Bioluminescence Resonance Energy Transfer (BRET)
por: Mulero, Miquel, et al.
Publicado: (2013)

Molecular basis of ligand-dependent Nurr1-RXRα activation
por: Yu, Xiaoyu, et al.
Publicado: (2023)

Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer
por: Zhao, Mohan, et al.
Publicado: (2022)

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury
por: van Neerven, Sabien, et al.
Publicado: (2007)

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
por: le Maire, Albane, et al.
Publicado: (2019)

Correction for Zhao et al., Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer
Publicado: (2023)

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists
por: Meijer, Femke A., et al.
Publicado: (2019)

Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγ/RXR Heterodimerization
por: Hu, Jiamiao, et al.
Publicado: (2018)

Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding
por: Rehó, Bálint, et al.
Publicado: (2023)

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes
por: Andrei, Sebastian A., et al.
Publicado: (2018)

Designed Spiroketal Protein Modulation
por: Scheepstra, Marcel, et al.
Publicado: (2017)

RXR Ligands Negatively Regulate Thrombosis and Hemostasis
por: Unsworth, Amanda J., et al.
Publicado: (2017)

Supramolecular Chemistry Targeting Proteins
por: van Dun, Sam, et al.
Publicado: (2017)

Molecular Evolution of Ultraspiracle Protein (USP/RXR) in Insects
por: Hult, Ekaterina F., et al.
Publicado: (2011)

RXRα Regulates the Development of Resident Tissue Macrophages
por: Philpott, Jordan, et al.
Publicado: (2022)

Microsecond MD Simulations to Explore the Structural and Energetic Differences between the Human RXRα-PPARγ vs. RXRα-PPARγ-DNA
por: Azam, Faizul, et al.
Publicado: (2022)

Solution Structures of PPARγ2/RXRα Complexes
por: Osz, Judit, et al.
Publicado: (2012)

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
por: Kojetin, Douglas J., et al.
Publicado: (2015)

RXR Expression in Marine Gastropods with Different Sensitivity to Imposex Development
por: Giulianelli, Sebastián, et al.
Publicado: (2020)

Cytoplasmic Localization of RXRα Determines Outcome in Breast Cancer
por: Zati zehni, Alaleh, et al.
Publicado: (2021)

Quantitative proteomic study of the plasma reveals acute phase response and LXR/RXR and FXR/RXR activation in the chronic unpredictable mild stress mouse model of depression
por: Yang, Chuangchuang, et al.
Publicado: (2018)

Multi-Omics Analysis Reveals Up-Regulation of APR Signaling, LXR/RXR and FXR/RXR Activation Pathways in Holstein Dairy Cows Exposed to High-Altitude Hypoxia
por: Kong, Zhiwei, et al.
Publicado: (2019)

Cooperativity basis for small-molecule stabilization of protein–protein interactions
por: de Vink, Pim J., et al.
Publicado: (2019)

Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?
por: Akram, Afia, et al.
Publicado: (2010)

Cross-Talk between PPARs and the Partners of RXR: A Molecular Perspective
por: Chan, Lap Shu Alan, et al.
Publicado: (2009)

Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ
por: Zhang, Haitao, et al.
Publicado: (2011)

Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex
por: Ricci, Clarisse G., et al.
Publicado: (2016)

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
por: Zhang, Jun, et al.
Publicado: (2011)

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages
por: Daniel, Bence, et al.
Publicado: (2014)

Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site
por: Chen, Fan, et al.
Publicado: (2014)

Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression
por: Saito-Hakoda, Akiko, et al.
Publicado: (2015)

Reciprocal Interaction of Wnt and RXR-α Pathways in Hepatocyte Development and Hepatocellular Carcinoma
por: Li, Jinyu, et al.
Publicado: (2015)

Overview of the structure-based non-genomic effects of the nuclear receptor RXRα
por: Chen, Liqun, et al.
Publicado: (2018)

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease
por: Mariani, M. M., et al.
Publicado: (2017)

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer
por: Korpal, Manav, et al.
Publicado: (2017)

Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer
por: Belorusova, Anna Y, et al.
Publicado: (2020)

Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
por: Delfosse, Vanessa, et al.
Publicado: (2021)

The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer
por: Chen, Fangfang, et al.
Publicado: (2021)

Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides
por: Dauwe, Yannick, et al.
Publicado: (2023)

Phase separation propensity of the intrinsically disordered AB region of human RXRβ
por: Sołtys, Katarzyna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eic8jitne2squ5qoiciin0klb7