iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance...

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Detalles Bibliográficos
Autores principales: Türker Şener, Leyla, Albeni̇z, Gürcan, Di̇nç, Bi̇rcan, Albeni̇z, Işil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609197/
https://www.ncbi.nlm.nih.gov/pubmed/28962095
http://dx.doi.org/10.3892/etm.2017.4781
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author Türker Şener, Leyla
Albeni̇z, Gürcan
Di̇nç, Bi̇rcan
Albeni̇z, Işil
author_facet Türker Şener, Leyla
Albeni̇z, Gürcan
Di̇nç, Bi̇rcan
Albeni̇z, Işil
author_sort Türker Şener, Leyla
collection PubMed
description The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity.
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spelling pubmed-56091972017-09-28 iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines Türker Şener, Leyla Albeni̇z, Gürcan Di̇nç, Bi̇rcan Albeni̇z, Işil Exp Ther Med Review The recently developed iCELLigence™ real-time cell analyzer (RTCA) can be used for the label-free real-time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity. The RTCA system uses 16-well microtiter plates with a gold microelectrode biosensor array that measures impedance when cells adhere to the microelectrodes causing an alternating current. By measuring the electric field generated in this process, the RTCA system can be used for the analysis of cell proliferation, viability, morphology and migration. The present review aimed to summarize the working method of the RTCA system, in addition to discussing the research performed using the system for various applications, including cancer drug discovery via measuring cytotoxicity. D.A. Spandidos 2017-09 2017-07-11 /pmc/articles/PMC5609197/ /pubmed/28962095 http://dx.doi.org/10.3892/etm.2017.4781 Text en Copyright: © Şener et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Türker Şener, Leyla
Albeni̇z, Gürcan
Di̇nç, Bi̇rcan
Albeni̇z, Işil
iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
title iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
title_full iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
title_fullStr iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
title_full_unstemmed iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
title_short iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
title_sort icelligence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609197/
https://www.ncbi.nlm.nih.gov/pubmed/28962095
http://dx.doi.org/10.3892/etm.2017.4781
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