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Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin

Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin...

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Autores principales: Wu, Zhuoxia, Zhang, Lianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609303/
https://www.ncbi.nlm.nih.gov/pubmed/28962194
http://dx.doi.org/10.3892/etm.2017.4807
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author Wu, Zhuoxia
Zhang, Lianbo
author_facet Wu, Zhuoxia
Zhang, Lianbo
author_sort Wu, Zhuoxia
collection PubMed
description Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI-1 and EZH2) were altered. In addition, the expression levels of these genes were associated with the expression of enzymes that regulate HA synthesis. Furthermore, the expression levels of PcG proteins differed between HSFs and ESFs, suggesting that PcG proteins serve a role in altering HA synthesis during the UVA-induced fibroblast aging process. This signaling pathway may represent a novel molecular mechanism regulating the photoaging of the skin. The findings of the present study provide important insights into the underlying mechanisms of photoaging of the human skin. Further studies are required to clarify the molecular mechanisms underling skin aging and to identify targets for the clinical treatment of photoaging.
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spelling pubmed-56093032017-09-28 Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin Wu, Zhuoxia Zhang, Lianbo Exp Ther Med Articles Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI-1 and EZH2) were altered. In addition, the expression levels of these genes were associated with the expression of enzymes that regulate HA synthesis. Furthermore, the expression levels of PcG proteins differed between HSFs and ESFs, suggesting that PcG proteins serve a role in altering HA synthesis during the UVA-induced fibroblast aging process. This signaling pathway may represent a novel molecular mechanism regulating the photoaging of the skin. The findings of the present study provide important insights into the underlying mechanisms of photoaging of the human skin. Further studies are required to clarify the molecular mechanisms underling skin aging and to identify targets for the clinical treatment of photoaging. D.A. Spandidos 2017-09 2017-07-19 /pmc/articles/PMC5609303/ /pubmed/28962194 http://dx.doi.org/10.3892/etm.2017.4807 Text en Copyright: © Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wu, Zhuoxia
Zhang, Lianbo
Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin
title Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin
title_full Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin
title_fullStr Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin
title_full_unstemmed Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin
title_short Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin
title_sort polycomb group proteins: novel molecules associated with ultraviolet a-induced photoaging of human skin
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609303/
https://www.ncbi.nlm.nih.gov/pubmed/28962194
http://dx.doi.org/10.3892/etm.2017.4807
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