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Comparison between serum magnesium levels of asphyxiated neonates and normal cases

Background: Asphyxia is one the most important causes of neonatal mortality and morbidity. It is suggested that magnesium may have a protective role against cellular damage during hypoxic brain insult, or change effect post-asphyxia consequences. Our study was performed for comparison of serum magne...

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Autores principales: Khalessi, Nasrin, Mazouri, Ali, Bassirnia, Mandana, Afsharkhas, Ladan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609322/
https://www.ncbi.nlm.nih.gov/pubmed/28955669
http://dx.doi.org/10.18869/mjiri.31.19
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author Khalessi, Nasrin
Mazouri, Ali
Bassirnia, Mandana
Afsharkhas, Ladan
author_facet Khalessi, Nasrin
Mazouri, Ali
Bassirnia, Mandana
Afsharkhas, Ladan
author_sort Khalessi, Nasrin
collection PubMed
description Background: Asphyxia is one the most important causes of neonatal mortality and morbidity. It is suggested that magnesium may have a protective role against cellular damage during hypoxic brain insult, or change effect post-asphyxia consequences. Our study was performed for comparison of serum magnesium in neonates with and without asphyxia. Methods: This study was done in Neonatal Ward of Ali-Asghar hospital, from January 2010 to 2011 in Tehran, Iran. Serum magnesium levels of seventy-six cases with a diagnosis of asphyxia grade 2 were compared with 76 normal newborns. Collected data including gestational age, sex, birth weight and serum magnesium levels were analyzed by SPSS software. Results: Of 152 neonates, 81 (53.3%) were male. Mean gestational age was 37.9 ± 1.07 weeks. Mean birth weights were 3172.9± 411.20 grams. Mean serum magnesium levels were compared in asphyxiated and normal neonates and between two groups significant difference was found (p=0.01). The odds ratio was 2.188 (with lower1.826, upper 2.626 and confidence interval 95 percent) which suggested a significant correlation between asphyxia and hypomagnesemia. Conclusion: This study showed that serum magnesium levels in neonates with asphyxia was significantly lower than normal neonates and asphyxia can lead to hypomagnesemia.
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spelling pubmed-56093222017-09-27 Comparison between serum magnesium levels of asphyxiated neonates and normal cases Khalessi, Nasrin Mazouri, Ali Bassirnia, Mandana Afsharkhas, Ladan Med J Islam Repub Iran Original Article Background: Asphyxia is one the most important causes of neonatal mortality and morbidity. It is suggested that magnesium may have a protective role against cellular damage during hypoxic brain insult, or change effect post-asphyxia consequences. Our study was performed for comparison of serum magnesium in neonates with and without asphyxia. Methods: This study was done in Neonatal Ward of Ali-Asghar hospital, from January 2010 to 2011 in Tehran, Iran. Serum magnesium levels of seventy-six cases with a diagnosis of asphyxia grade 2 were compared with 76 normal newborns. Collected data including gestational age, sex, birth weight and serum magnesium levels were analyzed by SPSS software. Results: Of 152 neonates, 81 (53.3%) were male. Mean gestational age was 37.9 ± 1.07 weeks. Mean birth weights were 3172.9± 411.20 grams. Mean serum magnesium levels were compared in asphyxiated and normal neonates and between two groups significant difference was found (p=0.01). The odds ratio was 2.188 (with lower1.826, upper 2.626 and confidence interval 95 percent) which suggested a significant correlation between asphyxia and hypomagnesemia. Conclusion: This study showed that serum magnesium levels in neonates with asphyxia was significantly lower than normal neonates and asphyxia can lead to hypomagnesemia. Iran University of Medical Sciences 2017-03-09 /pmc/articles/PMC5609322/ /pubmed/28955669 http://dx.doi.org/10.18869/mjiri.31.19 Text en © 2017 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Khalessi, Nasrin
Mazouri, Ali
Bassirnia, Mandana
Afsharkhas, Ladan
Comparison between serum magnesium levels of asphyxiated neonates and normal cases
title Comparison between serum magnesium levels of asphyxiated neonates and normal cases
title_full Comparison between serum magnesium levels of asphyxiated neonates and normal cases
title_fullStr Comparison between serum magnesium levels of asphyxiated neonates and normal cases
title_full_unstemmed Comparison between serum magnesium levels of asphyxiated neonates and normal cases
title_short Comparison between serum magnesium levels of asphyxiated neonates and normal cases
title_sort comparison between serum magnesium levels of asphyxiated neonates and normal cases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609322/
https://www.ncbi.nlm.nih.gov/pubmed/28955669
http://dx.doi.org/10.18869/mjiri.31.19
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