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[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression

[18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18...

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Autores principales: Dadone-Montaudié, Bérengère, Ambrosetti, Damien, Dufour, Maxime, Darcourt, Jacques, Almairac, Fabien, Coyne, John, Virolle, Thierry, Humbert, Olivier, Burel-Vandenbos, Fanny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609741/
https://www.ncbi.nlm.nih.gov/pubmed/28937983
http://dx.doi.org/10.1371/journal.pone.0184625
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author Dadone-Montaudié, Bérengère
Ambrosetti, Damien
Dufour, Maxime
Darcourt, Jacques
Almairac, Fabien
Coyne, John
Virolle, Thierry
Humbert, Olivier
Burel-Vandenbos, Fanny
author_facet Dadone-Montaudié, Bérengère
Ambrosetti, Damien
Dufour, Maxime
Darcourt, Jacques
Almairac, Fabien
Coyne, John
Virolle, Thierry
Humbert, Olivier
Burel-Vandenbos, Fanny
author_sort Dadone-Montaudié, Bérengère
collection PubMed
description [18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18F]-FDOPA uptake was correlated with level of LAT1 expression in BT. Twenty-eight BT (including 19 gliomas and 9 metastases) were investigated by [18F]-FDOPA-PET prior to surgery and by anti-LAT1 immunohistochemistry on surgical specimens. The quantitative [18F]-FDOPA measured parameters were SUVmax, SUVmean and SUVpeak. LAT1 expression was quantified using a score (0 to 400). A significant [18F]-FDOPA uptake was associated with a LAT1 score ≥ 100 (p = 0.02) but there was no linear correlation between intensity of [18F]-FDOPA uptake and score of LAT1 expression whatever the parameters considered. LAT1 expression alone is not sufficient to explain variation of intensity of [18F]-FDOPA uptake in BT.
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spelling pubmed-56097412017-10-09 [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression Dadone-Montaudié, Bérengère Ambrosetti, Damien Dufour, Maxime Darcourt, Jacques Almairac, Fabien Coyne, John Virolle, Thierry Humbert, Olivier Burel-Vandenbos, Fanny PLoS One Research Article [18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18F]-FDOPA uptake was correlated with level of LAT1 expression in BT. Twenty-eight BT (including 19 gliomas and 9 metastases) were investigated by [18F]-FDOPA-PET prior to surgery and by anti-LAT1 immunohistochemistry on surgical specimens. The quantitative [18F]-FDOPA measured parameters were SUVmax, SUVmean and SUVpeak. LAT1 expression was quantified using a score (0 to 400). A significant [18F]-FDOPA uptake was associated with a LAT1 score ≥ 100 (p = 0.02) but there was no linear correlation between intensity of [18F]-FDOPA uptake and score of LAT1 expression whatever the parameters considered. LAT1 expression alone is not sufficient to explain variation of intensity of [18F]-FDOPA uptake in BT. Public Library of Science 2017-09-22 /pmc/articles/PMC5609741/ /pubmed/28937983 http://dx.doi.org/10.1371/journal.pone.0184625 Text en © 2017 Dadone-Montaudié et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Dadone-Montaudié, Bérengère
Ambrosetti, Damien
Dufour, Maxime
Darcourt, Jacques
Almairac, Fabien
Coyne, John
Virolle, Thierry
Humbert, Olivier
Burel-Vandenbos, Fanny
[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression
title [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression
title_full [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression
title_fullStr [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression
title_full_unstemmed [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression
title_short [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression
title_sort [18f] fdopa standardized uptake values of brain tumors are not exclusively dependent on lat1 expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609741/
https://www.ncbi.nlm.nih.gov/pubmed/28937983
http://dx.doi.org/10.1371/journal.pone.0184625
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