Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis

Osteoblasts express two key molecules for osteoclast differentiation, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG), a soluble decoy receptor for RANKL. RANKL induces osteoclastogenesis, while OPG inhibits it by blocking the binding of RANKL to RANK, a cellular receptor of RAN...

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Detalles Bibliográficos
Autores principales: Ozaki, Yuki, Koide, Masanori, Furuya, Yuriko, Ninomiya, Tadashi, Yasuda, Hisataka, Nakamura, Midori, Kobayashi, Yasuhiro, Takahashi, Naoyuki, Yoshinari, Nobuo, Udagawa, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609750/
https://www.ncbi.nlm.nih.gov/pubmed/28937990
http://dx.doi.org/10.1371/journal.pone.0184904

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