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SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

Overexpression or pharmacological activation of SIRT1 has been shown to extend the lifespan of mice and protect against aging-related diseases. Here we show that pharmacological activation of SIRT1 protects in two models of osteoporosis. Ovariectomized female mice and aged male mice, models for post...

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Detalles Bibliográficos
Autores principales:	Zainabadi, Kayvan, Liu, Cassie J., Caldwell, Alison L. M., Guarente, Leonard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609767/ https://www.ncbi.nlm.nih.gov/pubmed/28937996 http://dx.doi.org/10.1371/journal.pone.0185236

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