Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression

The activation of retinoic acid–inducible gene I (RIG-I), an indispensable viral RNA sensor in mammals, is subtly regulated by ubiquitination. Although multiple ubiquitination sites at the amino terminus of RIG-I have been identified, their functional allocations in RIG-I activation remain elusive....

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Detalles Bibliográficos
Autores principales: Xian, Huifang, Xie, Weihong, Yang, Shuai, Liu, Qingxiang, Xia, Xiaojun, Jin, Shouheng, Sun, Tingzhe, Cui, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609842/
https://www.ncbi.nlm.nih.gov/pubmed/28948228
http://dx.doi.org/10.1126/sciadv.1701764

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