Metformin selectively targets redox control of complex I energy transduction

Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are likely to account for this difference. In pri...

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Detalles Bibliográficos
Autores principales: Cameron, Amy R., Logie, Lisa, Patel, Kashyap, Erhardt, Stefan, Bacon, Sandra, Middleton, Paul, Harthill, Jean, Forteath, Calum, Coats, Josh T., Kerr, Calum, Curry, Heather, Stewart, Derek, Sakamoto, Kei, Repiščák, Peter, Paterson, Martin J., Hassinen, Ilmo, McDougall, Gordon, Rena, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609876/
https://www.ncbi.nlm.nih.gov/pubmed/28942196
http://dx.doi.org/10.1016/j.redox.2017.08.018

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