Cargando…

Critical role of β1 integrin in postnatal beta-cell function and expansion

β1 integrin is essential for pancreatic beta-cell development and maintenance in rodents and humans. However, the effects of a temporal beta-cell specific β1 integrin knockout on adult islet function are unknown. We utilized a mouse insulin 1 promoter driven tamoxifen-inducible Cre-recombinase β1 in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peart, Jason, Li, Jinming, Lee, Hojun, Riopel, Matthew, Feng, Zhi-Chao, Wang, Rennian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609893/ https://www.ncbi.nlm.nih.gov/pubmed/28968961 http://dx.doi.org/10.18632/oncotarget.17969

Ejemplares similares

Inhibition of Gsk3β activity improves β-cell function in c-Kit(Wv/+) male mice
por: Feng, Zhi-Chao, et al.
Publicado: (2012)

Expression and function of αβ1 integrins in pancretic beta (INS-1) cells
por: Krishnamurthy, Mansa, et al.
Publicado: (2008)

β-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response
por: Trinder, Mark, et al.
Publicado: (2016)

Ultrastructural and immunohistochemical analysis of the 8-20 week human fetal pancreas
por: Riopel, Matthew, et al.
Publicado: (2014)

Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions
por: Chen, Bijun, et al.
Publicado: (2015)

Collagen IV-β1-Integrin Influences INS-1 Cell Insulin Secretion via Enhanced SNARE Protein Expression
por: Barillaro, Malina, et al.
Publicado: (2022)

Survivin Is Required for Beta-Cell Mass Expansion in the Pancreatic Duct-Ligated Mouse Model
por: Wu, Xiaohong, et al.
Publicado: (2012)

Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
por: Jiang, Yuying, et al.
Publicado: (2008)

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells
por: Paul, Leena, et al.
Publicado: (2016)

β1 Integrin-Mediated Adhesion Signalling Is Essential for Epidermal Progenitor Cell Expansion
por: Piwko-Czuchra, Aleksandra, et al.
Publicado: (2009)

Role of β1 integrin in thrombocytopoiesis
por: Mazzarini, Maria, et al.
Publicado: (2021)

Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans
por: Swarbrick, Gwendolyn M., et al.
Publicado: (2020)

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway
por: Rapisarda, Valentina, et al.
Publicado: (2017)

Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy
por: Shi, Yingchao, et al.
Publicado: (2022)

Plant toxin β-ODAP activates integrin β1 and focal adhesion: A critical pathway to cause neurolathyrism
por: Tan, Rui-Yue, et al.
Publicado: (2017)

TGF-Beta Receptor II Is Critical for Osteogenic Progenitor Cell Proliferation and Differentiation During Postnatal Alveolar Bone Formation
por: Xu, Chunmei, et al.
Publicado: (2021)

Integrin signaling is critical for pathological angiogenesis
por: Mahabeleshwar, Ganapati H., et al.
Publicado: (2006)

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
Publicado: (1996)

The critical role of membralin in postnatal motor neuron survival and disease
por: Yang, Bo, et al.
Publicado: (2015)

Cytoplasmic and transmembrane domains of integrin beta 1 and beta 3 subunits are functionally interchangeable
Publicado: (1991)

Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation
por: Naylor, Matthew J., et al.
Publicado: (2005)

β(1) Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo
por: Werr, Joachim, et al.
Publicado: (1998)

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging
por: Nishimura, Mayuko, et al.
Publicado: (2014)

The role of integrins in TGFβ activation in the tumour stroma
por: Khan, Zareen, et al.
Publicado: (2016)

Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein
Publicado: (1995)

Calcium Channels in Postnatal Development of Rat Pancreatic Beta Cells and Their Role in Insulin Secretion
por: García-Delgado, Neivys, et al.
Publicado: (2018)

RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice
por: Gutiérrez, Jaime, et al.
Publicado: (2015)

Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function
por: Lu, Zhenwei, et al.
Publicado: (2016)

Conditional deletion of β1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality
por: Jones, Robert G., et al.
Publicado: (2006)

The Changing Integrin Expression and a Role for Integrin β8 in the Chondrogenic Differentiation of Mesenchymal Stem Cells
por: LaPointe, Vanessa L. S., et al.
Publicado: (2013)

Role of alpha 2 beta 1- and alpha 3 beta 1-integrin in the peritoneal implantation of scirrhous gastric carcinoma.
por: Nishimura, S., et al.
Publicado: (1996)

Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration
Publicado: (1994)

Interaction of integrins alpha 3 beta 1 and alpha 2 beta 1: potential role in keratinocyte intercellular adhesion
Publicado: (1993)

Integrin αvβ5 heterodimer is a specific marker of human pancreatic beta cells
por: Schiesser, Jacqueline V., et al.
Publicado: (2021)

Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment
por: Brzozowska, Ewa, et al.
Publicado: (2022)

Novel function for beta 1 integrins in keratinocyte cell-cell interactions
Publicado: (1990)

Structure/function analysis of the integrin beta 1 subunit by epitope mapping
Publicado: (1993)

The intracellular functions of alpha6beta4 integrin are regulated by EGF
Publicado: (1996)

The behavior of osteoblast-like cells on various substrates with functional blocking of integrin-β1 and integrin-β3
por: Siebers, M. C., et al.
Publicado: (2007)

Activation of Pancreatic Stellate Cells Is Beneficial for Exocrine but Not Endocrine Cell Differentiation in the Developing Human Pancreas
por: Li, Jinming, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s1phlj8cu233u9p3ul888dota3