Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation

Targeted therapeutic agents, such as inhibitors of epithelial growth factor receptor (EGFR), have transformed the management of non-small cell lung cancer (NSCLC) patients. MET-amplified NSCLC cells display resistance to EGFR-targeting agents, but are addicted to MET signaling for survival and proli...

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Detalles Bibliográficos
Autores principales: Owusu, Benjamin Y., Thomas, Shantasia, Venukadasula, Phanindra, Han, Zhenfu, Janetka, James W., Galemmo, Robert A., Klampfer, Lidija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609899/
https://www.ncbi.nlm.nih.gov/pubmed/28968967
http://dx.doi.org/10.18632/oncotarget.18260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609899/
https://www.ncbi.nlm.nih.gov/pubmed/28968967
http://dx.doi.org/10.18632/oncotarget.18260

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