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Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine
Vitamin D deficiency will lead to insulin resistance. In the current study, vitamin D3 1α-Hydroxylase [“1α(OH)ase”] knockout mice were generated to mimic vitamin D deficiency in vivo. As compared to the wild-type mice, the liver tissues of the knockout mice showed impaired insulin signaling, decreas...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609920/ https://www.ncbi.nlm.nih.gov/pubmed/28968988 http://dx.doi.org/10.18632/oncotarget.18793 |
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author | Cui, Zhao-Hui Yuan, Qi Mao, Li Chen, Feng-Li Ji, Feng Tao, Sha |
author_facet | Cui, Zhao-Hui Yuan, Qi Mao, Li Chen, Feng-Li Ji, Feng Tao, Sha |
author_sort | Cui, Zhao-Hui |
collection | PubMed |
description | Vitamin D deficiency will lead to insulin resistance. In the current study, vitamin D3 1α-Hydroxylase [“1α(OH)ase”] knockout mice were generated to mimic vitamin D deficiency in vivo. As compared to the wild-type mice, the liver tissues of the knockout mice showed impaired insulin signaling, decreased glucose transporter 4 expression and increased reactive oxygen species production. Meanwhile, p53-p21 activation, apoptosis intensity and pro-inflammatory cytokines (IL-6, IL-1 and MIP-1α) level were significantly increased in the knockout mice livers. Significantly, such effects in the knockout mice were largely attenuated by supplement with anti-oxidant n-acetylcysteine (NAC). Remarkably, insulin resistance and metabolic abnormalities in the knockout mice were largely alleviated after treatment of NAC. Therefore, inhibition of oxidative stress by NAC alleviated insulin resistance in vitamin D-deficient mice. Oxidative stress could be the primary cause of insulin resistance by vitamin D deficiency. |
format | Online Article Text |
id | pubmed-5609920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56099202017-09-29 Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine Cui, Zhao-Hui Yuan, Qi Mao, Li Chen, Feng-Li Ji, Feng Tao, Sha Oncotarget Research Paper Vitamin D deficiency will lead to insulin resistance. In the current study, vitamin D3 1α-Hydroxylase [“1α(OH)ase”] knockout mice were generated to mimic vitamin D deficiency in vivo. As compared to the wild-type mice, the liver tissues of the knockout mice showed impaired insulin signaling, decreased glucose transporter 4 expression and increased reactive oxygen species production. Meanwhile, p53-p21 activation, apoptosis intensity and pro-inflammatory cytokines (IL-6, IL-1 and MIP-1α) level were significantly increased in the knockout mice livers. Significantly, such effects in the knockout mice were largely attenuated by supplement with anti-oxidant n-acetylcysteine (NAC). Remarkably, insulin resistance and metabolic abnormalities in the knockout mice were largely alleviated after treatment of NAC. Therefore, inhibition of oxidative stress by NAC alleviated insulin resistance in vitamin D-deficient mice. Oxidative stress could be the primary cause of insulin resistance by vitamin D deficiency. Impact Journals LLC 2017-06-28 /pmc/articles/PMC5609920/ /pubmed/28968988 http://dx.doi.org/10.18632/oncotarget.18793 Text en Copyright: © 2017 Cui et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Cui, Zhao-Hui Yuan, Qi Mao, Li Chen, Feng-Li Ji, Feng Tao, Sha Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine |
title | Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine |
title_full | Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine |
title_fullStr | Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine |
title_full_unstemmed | Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine |
title_short | Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine |
title_sort | insulin resistance in vitamin d-deficient mice is alleviated by n-acetylcysteine |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609920/ https://www.ncbi.nlm.nih.gov/pubmed/28968988 http://dx.doi.org/10.18632/oncotarget.18793 |
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