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Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma
The aim of this study was to evaluate the conservative management and prognosis of primary vaginal endodermal sinus tumor and rhabdomyosarcoma in children. Medical records of children with vaginal endodermal sinus tumor and rhabdomyosarcoma between 1996 and 2015 were reviewed. A total of 24 patients...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609936/ https://www.ncbi.nlm.nih.gov/pubmed/28969004 http://dx.doi.org/10.18632/oncotarget.18829 |
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author | Xie, Weimin Shen, Keng Yang, Jiaxin Cao, Dongyan Yu, Mei Wang, Yao |
author_facet | Xie, Weimin Shen, Keng Yang, Jiaxin Cao, Dongyan Yu, Mei Wang, Yao |
author_sort | Xie, Weimin |
collection | PubMed |
description | The aim of this study was to evaluate the conservative management and prognosis of primary vaginal endodermal sinus tumor and rhabdomyosarcoma in children. Medical records of children with vaginal endodermal sinus tumor and rhabdomyosarcoma between 1996 and 2015 were reviewed. A total of 24 patients (median age, 12 months; range, 7–44 months) were included in this study, comprising 17 patients with endodermal sinus tumor and 7 patients with rhabdomyosarcoma. Among the 17 patients with endodermal sinus tumor, 15 were initially treated at our hospital with chemotherapy alone, and 2 were initially treated in other hospitals with conservative surgery and chemotherapy. All 7 patients with botryoid rhabdomyosarcoma received chemotherapy without well-defined protocols. At a median follow-up of 51 months (range, 4–237 months), 3 patients (12.5%; 1 with endodermal sinus tumor and 2 with rhabdomyosarcoma) developed recurrence. At the last follow-up, 22 patients (91.7%) were alive without evidence of disease, 1 patient with botryoid rhabdomyosarcoma died of disease progression, and 1 patient with endodermal sinus tumor died of respiratory and circulatory failure. To allow preservation of sexual and reproductive function, conservative therapeutic strategies should be considered for children with vaginal endodermal sinus tumor and botryoid rhabdomyosarcoma. |
format | Online Article Text |
id | pubmed-5609936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56099362017-09-29 Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma Xie, Weimin Shen, Keng Yang, Jiaxin Cao, Dongyan Yu, Mei Wang, Yao Oncotarget Research Paper The aim of this study was to evaluate the conservative management and prognosis of primary vaginal endodermal sinus tumor and rhabdomyosarcoma in children. Medical records of children with vaginal endodermal sinus tumor and rhabdomyosarcoma between 1996 and 2015 were reviewed. A total of 24 patients (median age, 12 months; range, 7–44 months) were included in this study, comprising 17 patients with endodermal sinus tumor and 7 patients with rhabdomyosarcoma. Among the 17 patients with endodermal sinus tumor, 15 were initially treated at our hospital with chemotherapy alone, and 2 were initially treated in other hospitals with conservative surgery and chemotherapy. All 7 patients with botryoid rhabdomyosarcoma received chemotherapy without well-defined protocols. At a median follow-up of 51 months (range, 4–237 months), 3 patients (12.5%; 1 with endodermal sinus tumor and 2 with rhabdomyosarcoma) developed recurrence. At the last follow-up, 22 patients (91.7%) were alive without evidence of disease, 1 patient with botryoid rhabdomyosarcoma died of disease progression, and 1 patient with endodermal sinus tumor died of respiratory and circulatory failure. To allow preservation of sexual and reproductive function, conservative therapeutic strategies should be considered for children with vaginal endodermal sinus tumor and botryoid rhabdomyosarcoma. Impact Journals LLC 2017-06-28 /pmc/articles/PMC5609936/ /pubmed/28969004 http://dx.doi.org/10.18632/oncotarget.18829 Text en Copyright: © 2017 Xie et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Xie, Weimin Shen, Keng Yang, Jiaxin Cao, Dongyan Yu, Mei Wang, Yao Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma |
title | Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma |
title_full | Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma |
title_fullStr | Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma |
title_full_unstemmed | Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma |
title_short | Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma |
title_sort | conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609936/ https://www.ncbi.nlm.nih.gov/pubmed/28969004 http://dx.doi.org/10.18632/oncotarget.18829 |
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