Cargando…
Repression of intestinal transporters and FXR-FGF15 signaling explains bile acids dysregulation in experimental colitis-associated colon cancer
Bile acids (BAs) are important endogenous signaling molecules that play vital roles in the pathological development of various diseases including colitis-associated cancer (CAC). BAs were previously found dysregulated under conditions of CAC; however, the exact patterns and underlying molecular mech...
Autores principales: | Cao, Lijuan, Che, Yuan, Meng, Tuo, Deng, Shanshan, Zhang, Jun, Zhao, Min, Xu, Wanfeng, Wang, Dandan, Pu, Zhichen, Wang, Guangji, Hao, Haiping |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609951/ https://www.ncbi.nlm.nih.gov/pubmed/28969019 http://dx.doi.org/10.18632/oncotarget.18885 |
Ejemplares similares
-
PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis
por: Zhou, Xueyan, et al.
Publicado: (2014) -
Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis
por: Katafuchi, Takeshi, et al.
Publicado: (2022) -
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
por: Cui, Shuang, et al.
Publicado: (2023) -
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
por: Byun, Sangwon, et al.
Publicado: (2018) -
Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells
por: Pu, Zhichen, et al.
Publicado: (2019)