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Increased risk for diabetes mellitus in patients with carbon monoxide poisoning

Carbon monoxide poisoning (COP) causes hypoxic injury and inflammatory and immunological reactions in the brain and local organs including the pancreas. Therefore, it is plausible that COP may increase the risk for developing diabetes mellitus (DM), but studies on this possible association are limit...

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Autores principales: Huang, Chien-Cheng, Ho, Chung-Han, Chen, Yi-Chen, Lin, Hung-Jung, Hsu, Chien-Chin, Wang, Jhi-Joung, Su, Shih-Bin, Guo, How-Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609952/
https://www.ncbi.nlm.nih.gov/pubmed/28969020
http://dx.doi.org/10.18632/oncotarget.18887
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author Huang, Chien-Cheng
Ho, Chung-Han
Chen, Yi-Chen
Lin, Hung-Jung
Hsu, Chien-Chin
Wang, Jhi-Joung
Su, Shih-Bin
Guo, How-Ran
author_facet Huang, Chien-Cheng
Ho, Chung-Han
Chen, Yi-Chen
Lin, Hung-Jung
Hsu, Chien-Chin
Wang, Jhi-Joung
Su, Shih-Bin
Guo, How-Ran
author_sort Huang, Chien-Cheng
collection PubMed
description Carbon monoxide poisoning (COP) causes hypoxic injury and inflammatory and immunological reactions in the brain and local organs including the pancreas. Therefore, it is plausible that COP may increase the risk for developing diabetes mellitus (DM), but studies on this possible association are limited. We conducted a nationwide study in Taiwan to fill the data gap. We used the Nationwide Poisoning Database and the Longitudinal Health Insurance Database 2000 to identify all COP patients diagnosed between 1999 and 2012 (the study cohort) and then construct a comparison cohort of patients without COP through matching at 1:3 by the index date and age. The risk for DM between the two cohorts was compared by following up until 2013. We also investigated the independent predictors for DM in all the patients. During the study period, 22,308 COP patients were identified, and 66,924 non-COP patients were included in the comparison cohort accordingly. Patients with COP had an increased risk for DM with an adjusted hazard ratio (AHR) of 1.92 (95% confidence interval [CI]: 1.79–2.06) after adjusting for age, sex, comorbidities, and monthly income, especially in the subgroups of age <35 years, age ≥ 65 years, female sex, and comorbidities with congestive heart failure, hyperthyroidism, and polycystic ovary syndrome. Cox proportional hazard regression analysis showed that the increased risk for DM was highest in the first month after COP (AHR= 3.38; 95% CI: 2.29–4.99) and lasted even after 4 years (AHR= 1.82; 95% CI: 1.62–2.04). We found that COP, older age, male sex, hypertension, hyperlipidemia, hyperuricemia, and low monthly income were independent predictors for DM. Intervention studies are needed to validate the results and delineate the detailed mechanisms.
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spelling pubmed-56099522017-09-29 Increased risk for diabetes mellitus in patients with carbon monoxide poisoning Huang, Chien-Cheng Ho, Chung-Han Chen, Yi-Chen Lin, Hung-Jung Hsu, Chien-Chin Wang, Jhi-Joung Su, Shih-Bin Guo, How-Ran Oncotarget Research Paper Carbon monoxide poisoning (COP) causes hypoxic injury and inflammatory and immunological reactions in the brain and local organs including the pancreas. Therefore, it is plausible that COP may increase the risk for developing diabetes mellitus (DM), but studies on this possible association are limited. We conducted a nationwide study in Taiwan to fill the data gap. We used the Nationwide Poisoning Database and the Longitudinal Health Insurance Database 2000 to identify all COP patients diagnosed between 1999 and 2012 (the study cohort) and then construct a comparison cohort of patients without COP through matching at 1:3 by the index date and age. The risk for DM between the two cohorts was compared by following up until 2013. We also investigated the independent predictors for DM in all the patients. During the study period, 22,308 COP patients were identified, and 66,924 non-COP patients were included in the comparison cohort accordingly. Patients with COP had an increased risk for DM with an adjusted hazard ratio (AHR) of 1.92 (95% confidence interval [CI]: 1.79–2.06) after adjusting for age, sex, comorbidities, and monthly income, especially in the subgroups of age <35 years, age ≥ 65 years, female sex, and comorbidities with congestive heart failure, hyperthyroidism, and polycystic ovary syndrome. Cox proportional hazard regression analysis showed that the increased risk for DM was highest in the first month after COP (AHR= 3.38; 95% CI: 2.29–4.99) and lasted even after 4 years (AHR= 1.82; 95% CI: 1.62–2.04). We found that COP, older age, male sex, hypertension, hyperlipidemia, hyperuricemia, and low monthly income were independent predictors for DM. Intervention studies are needed to validate the results and delineate the detailed mechanisms. Impact Journals LLC 2017-06-29 /pmc/articles/PMC5609952/ /pubmed/28969020 http://dx.doi.org/10.18632/oncotarget.18887 Text en Copyright: © 2017 Huang et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Huang, Chien-Cheng
Ho, Chung-Han
Chen, Yi-Chen
Lin, Hung-Jung
Hsu, Chien-Chin
Wang, Jhi-Joung
Su, Shih-Bin
Guo, How-Ran
Increased risk for diabetes mellitus in patients with carbon monoxide poisoning
title Increased risk for diabetes mellitus in patients with carbon monoxide poisoning
title_full Increased risk for diabetes mellitus in patients with carbon monoxide poisoning
title_fullStr Increased risk for diabetes mellitus in patients with carbon monoxide poisoning
title_full_unstemmed Increased risk for diabetes mellitus in patients with carbon monoxide poisoning
title_short Increased risk for diabetes mellitus in patients with carbon monoxide poisoning
title_sort increased risk for diabetes mellitus in patients with carbon monoxide poisoning
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609952/
https://www.ncbi.nlm.nih.gov/pubmed/28969020
http://dx.doi.org/10.18632/oncotarget.18887
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