Cargando…

Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma

Cytosine5-hyxymethylation (5hmC)which is a new epigenetic modification form plays important roles in the development and progression of tumors. In the present study, we observed that levels of 5hmC in the promoter region of Von Hippel-Lindau (VHL) were lower in 97 samples of renal clear cell carcino...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, En-Guang, Bai, Yu-Feng, Cao, Wei, Cao, Yan, Huang, Yong-Gang, Cheng, Huan-Chen, An, Rui-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609960/ https://www.ncbi.nlm.nih.gov/pubmed/28969028 http://dx.doi.org/10.18632/oncotarget.19070

Ejemplares similares

Hydroxymethylated cytosine in development and disease
por: Pfeifer, Gerd P
Publicado: (2013)

Enzymatic approaches for profiling cytosine methylation and hydroxymethylation
por: Wang, Tong, et al.
Publicado: (2021)

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
por: Hashimoto, Hideharu, et al.
Publicado: (2012)

Development and validation of a VHL-associated immune prognostic signature for clear cell renal cell carcinoma
por: Zhang, Jin, et al.
Publicado: (2020)

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression
por: Ponnaluri, V. K. Chaithanya, et al.
Publicado: (2016)

Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue
por: Wilkins, Owen M., et al.
Publicado: (2019)

Hydroxymethylated Cytosines Are Associated with Elevated C to G Transversion Rates
por: Supek, Fran, et al.
Publicado: (2014)

Cytosine methylation and hydroxymethylation mark DNA for elimination in Oxytricha trifallax
por: Bracht, John R, et al.
Publicado: (2012)

Cytosine methylation and hydroxymethylation mark DNA for elimination in Oxytricha trifallax
por: Bracht, John R, et al.
Publicado: (2013)

Cell Cycle-Dependent Turnover of 5-Hydroxymethyl Cytosine in Mouse Embryonic Stem Cells
por: Otani, Junji, et al.
Publicado: (2013)

Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
por: TAYLOR, CLAIRE, et al.
Publicado: (2012)

Identification and validation of the clinical roles of the VHL-related LncRNAs in clear cell renal cell carcinoma
por: Yang, Wuping, et al.
Publicado: (2021)

Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine
por: Crake, Rebekah L. I., et al.
Publicado: (2022)

VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
por: Gao, Yao-Hui, et al.
Publicado: (2017)

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance
por: Razafinjatovo, Caroline, et al.
Publicado: (2016)

Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines
por: Wang, Xuechun, et al.
Publicado: (2022)

Targeting HIF2α Translation with Tempol in VHL-Deficient Clear Cell Renal Cell Carcinoma
por: Sourbier, Carole, et al.
Publicado: (2012)

Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma
por: Noonan, Haley R., et al.
Publicado: (2016)

VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma
por: Ilic, Bojana B, et al.
Publicado: (2018)

VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma
por: Ganner, Athina, et al.
Publicado: (2021)

The Clinical and Molecular Features in the VHL Renal Cancers; Close or Distant Relatives with Sporadic Clear Cell Renal Cell Carcinoma?
por: Cinque, Alessandra, et al.
Publicado: (2022)

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
por: McRonald, Fiona E, et al.
Publicado: (2009)

Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2α
por: Fan, Yang, et al.
Publicado: (2016)

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
por: Moore, Lee E., et al.
Publicado: (2011)

Co-Localization of DNA i-Motif-Forming Sequences and 5-Hydroxymethyl-cytosines in Human Embryonic Stem Cells
por: Bhavsar-Jog, Yogini P., et al.
Publicado: (2019)

Association between the Cytosine Hydroxymethylation and the Expression of microRNA in Multiple Sclerosis in Polish Population
por: Basak, Justyna, et al.
Publicado: (2023)

An integrated computational approach can classify VHL missense mutations according to risk of clear cell renal carcinoma
por: Gossage, Lucy, et al.
Publicado: (2014)

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review
por: Kim, Hyeong Su, et al.
Publicado: (2018)

Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice
por: Harlander, Sabine, et al.
Publicado: (2017)

Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance
por: Mazumder, Sonia, et al.
Publicado: (2023)

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer
por: Stewart, Grant D., et al.
Publicado: (2016)

Understanding the structural and dynamic consequences of DNA epigenetic modifications: Computational insights into cytosine methylation and hydroxymethylation
por: Carvalho, Alexandra T P, et al.
Publicado: (2015)

DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes
por: Hohos, Natalie M., et al.
Publicado: (2016)

Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation
por: Moore, L E, et al.
Publicado: (2012)

Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC)
por: Martin, Benedicte, et al.
Publicado: (2013)

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
por: Bailey, Sean T., et al.
Publicado: (2017)

PBX1, EMCN and ERG are associated with the sub-clusters and the prognosis of VHL mutant clear cell renal cell carcinoma
por: Wang, Haiwei, et al.
Publicado: (2022)

VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates the axon guidance genes robo2 and slit in Drosophila
por: Singh, Badri Nath, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_16gcnuh9e8cc25c9c32a6i7c6s