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PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer

While the prognosis of gastric cancer (GC) remains poor, PD-1 and PD-L1/L2 are promising prognostic biomarkers. We evaluated PD-1 and PD-L1/L2 expression in tumor cells (TCs) and tumor-infiltrating immune cells (TIICs). We determined the Helicobacter pylori (Hp) and Epstein-Barr virus (EBV) infectio...

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Autores principales: Wu, Yanhua, Cao, Donghui, Qu, Limei, Cao, Xueyuan, Jia, Zhifang, Zhao, Tiancheng, Wang, Quan, Jiang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609984/
https://www.ncbi.nlm.nih.gov/pubmed/28969052
http://dx.doi.org/10.18632/oncotarget.19318
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author Wu, Yanhua
Cao, Donghui
Qu, Limei
Cao, Xueyuan
Jia, Zhifang
Zhao, Tiancheng
Wang, Quan
Jiang, Jing
author_facet Wu, Yanhua
Cao, Donghui
Qu, Limei
Cao, Xueyuan
Jia, Zhifang
Zhao, Tiancheng
Wang, Quan
Jiang, Jing
author_sort Wu, Yanhua
collection PubMed
description While the prognosis of gastric cancer (GC) remains poor, PD-1 and PD-L1/L2 are promising prognostic biomarkers. We evaluated PD-1 and PD-L1/L2 expression in tumor cells (TCs) and tumor-infiltrating immune cells (TIICs). We determined the Helicobacter pylori (Hp) and Epstein-Barr virus (EBV) infection status in a GC cohort (n=340), then analyzed the relationship between the expression of PD-1, PD-L1/L2 and GC prognosis. We found that PD-1, PD-L1, and PD-L2 mRNA levels were up-regulated in GC tissues, and were positively correlated with one another (P=0.043, P=0.008 and P=0.035). PD-1 protein expression in TIICs was observed in 22.6% of GC patients. The PD-L1 and PD-L2 positivity rates were 40.3% and 53.8% in TCs, respectively, and 60.0% and 60.9% in TIICs, respectively. PD-L1 was up-regulated in EBV-infected GC patients in both TCs (P=0.009) and TIICs (P=0.003). Hp status was not associated with PD-1 or PD-L1/PD-L2 expression. In TIICs, PD-L1 expression was independently associated with better GC prognosis (HR=0.72, 95%CI: 0.53-0.99). Co-expression of PD-1 and PD-L1, but not PD-L2, was a favorable prognostic marker that indicated a dose effect on the mortality risk of GC patients (P-value for trend=0.005). Comprehensive evaluation of PD-1 and PD-L1 in TCs and TIICs could help predict the prognosis of gastric cancers, as well as reveal patients who might benefit from targeted treatment.
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spelling pubmed-56099842017-09-29 PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer Wu, Yanhua Cao, Donghui Qu, Limei Cao, Xueyuan Jia, Zhifang Zhao, Tiancheng Wang, Quan Jiang, Jing Oncotarget Research Paper While the prognosis of gastric cancer (GC) remains poor, PD-1 and PD-L1/L2 are promising prognostic biomarkers. We evaluated PD-1 and PD-L1/L2 expression in tumor cells (TCs) and tumor-infiltrating immune cells (TIICs). We determined the Helicobacter pylori (Hp) and Epstein-Barr virus (EBV) infection status in a GC cohort (n=340), then analyzed the relationship between the expression of PD-1, PD-L1/L2 and GC prognosis. We found that PD-1, PD-L1, and PD-L2 mRNA levels were up-regulated in GC tissues, and were positively correlated with one another (P=0.043, P=0.008 and P=0.035). PD-1 protein expression in TIICs was observed in 22.6% of GC patients. The PD-L1 and PD-L2 positivity rates were 40.3% and 53.8% in TCs, respectively, and 60.0% and 60.9% in TIICs, respectively. PD-L1 was up-regulated in EBV-infected GC patients in both TCs (P=0.009) and TIICs (P=0.003). Hp status was not associated with PD-1 or PD-L1/PD-L2 expression. In TIICs, PD-L1 expression was independently associated with better GC prognosis (HR=0.72, 95%CI: 0.53-0.99). Co-expression of PD-1 and PD-L1, but not PD-L2, was a favorable prognostic marker that indicated a dose effect on the mortality risk of GC patients (P-value for trend=0.005). Comprehensive evaluation of PD-1 and PD-L1 in TCs and TIICs could help predict the prognosis of gastric cancers, as well as reveal patients who might benefit from targeted treatment. Impact Journals LLC 2017-07-18 /pmc/articles/PMC5609984/ /pubmed/28969052 http://dx.doi.org/10.18632/oncotarget.19318 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Wu, Yanhua
Cao, Donghui
Qu, Limei
Cao, Xueyuan
Jia, Zhifang
Zhao, Tiancheng
Wang, Quan
Jiang, Jing
PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer
title PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer
title_full PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer
title_fullStr PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer
title_full_unstemmed PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer
title_short PD-1 and PD-L1 co-expression predicts favorable prognosis in gastric cancer
title_sort pd-1 and pd-l1 co-expression predicts favorable prognosis in gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609984/
https://www.ncbi.nlm.nih.gov/pubmed/28969052
http://dx.doi.org/10.18632/oncotarget.19318
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