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Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress

Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress is involved in diabetic cognitive impairment. Hydrogen sulfide (H(2)S) attenuates the learning and memory decline in experimental Alzheimer's disease and inhibits...

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Autores principales: Zou, Wei, Yuan, Juan, Tang, Zhuo-Jun, Wei, Hai-Jun, Zhu, Wei-Wen, Zhang, Ping, Gu, Hong-Feng, Wang, Chun-Yan, Tang, Xiao-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609995/
https://www.ncbi.nlm.nih.gov/pubmed/28969063
http://dx.doi.org/10.18632/oncotarget.19448
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author Zou, Wei
Yuan, Juan
Tang, Zhuo-Jun
Wei, Hai-Jun
Zhu, Wei-Wen
Zhang, Ping
Gu, Hong-Feng
Wang, Chun-Yan
Tang, Xiao-Qing
author_facet Zou, Wei
Yuan, Juan
Tang, Zhuo-Jun
Wei, Hai-Jun
Zhu, Wei-Wen
Zhang, Ping
Gu, Hong-Feng
Wang, Chun-Yan
Tang, Xiao-Qing
author_sort Zou, Wei
collection PubMed
description Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress is involved in diabetic cognitive impairment. Hydrogen sulfide (H(2)S) attenuates the learning and memory decline in experimental Alzheimer's disease and inhibits the hippocampal ER stress in homocysteine-exposed rats. Therefore, this aim of the present work was to investigate whether H(2)S ameliorates the diabetic cognitive dysfunction involving inhibition of hippocampal ER stress. In the present work, we found that stretozotocin (STZ, 40 mg/kg)-induced diabetic rats exhibited impairment in cognitive function, as judged by the novel objective recognition task (NOR) test, the Y-maze test and the Morris water maze (MWM) test. Notably, treatment of diabetic rats with sodium hydrosulfide (NaHS, a donor of H(2)S, 30 or 100 μmol/kg/d, for 30 d) significantly reversed diabetes-induced impairment in cognitive function. We also found that STZ (40 mg/kg)-induced diabetic rats exhibited hippocampal ER stress, as evidenced by upregulations of glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), and cleaved caspase-12 in the hippocampus. However, treatment with NaHS (30 or 100 μmol/kg/d, for 30 d) markedly suppressed the increases in GRP78, CHOP, and cleaved caspase-12 expressions in the hippocampus of diabetic rats. In addition, we noted that NaHS (30 or 100 μmol/kg/d, for 30 d) significantly enhanced the generation of hippocampal endogenous H(2)S in STZ-induced diabetic rats. These results suggest that H(2)S exhibits therapeutic potential for diabetes-associated cognitive dysfunction, which is most likely related to its protective effects against hippocampal ER stress.
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spelling pubmed-56099952017-09-29 Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress Zou, Wei Yuan, Juan Tang, Zhuo-Jun Wei, Hai-Jun Zhu, Wei-Wen Zhang, Ping Gu, Hong-Feng Wang, Chun-Yan Tang, Xiao-Qing Oncotarget Research Paper Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress is involved in diabetic cognitive impairment. Hydrogen sulfide (H(2)S) attenuates the learning and memory decline in experimental Alzheimer's disease and inhibits the hippocampal ER stress in homocysteine-exposed rats. Therefore, this aim of the present work was to investigate whether H(2)S ameliorates the diabetic cognitive dysfunction involving inhibition of hippocampal ER stress. In the present work, we found that stretozotocin (STZ, 40 mg/kg)-induced diabetic rats exhibited impairment in cognitive function, as judged by the novel objective recognition task (NOR) test, the Y-maze test and the Morris water maze (MWM) test. Notably, treatment of diabetic rats with sodium hydrosulfide (NaHS, a donor of H(2)S, 30 or 100 μmol/kg/d, for 30 d) significantly reversed diabetes-induced impairment in cognitive function. We also found that STZ (40 mg/kg)-induced diabetic rats exhibited hippocampal ER stress, as evidenced by upregulations of glucose regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), and cleaved caspase-12 in the hippocampus. However, treatment with NaHS (30 or 100 μmol/kg/d, for 30 d) markedly suppressed the increases in GRP78, CHOP, and cleaved caspase-12 expressions in the hippocampus of diabetic rats. In addition, we noted that NaHS (30 or 100 μmol/kg/d, for 30 d) significantly enhanced the generation of hippocampal endogenous H(2)S in STZ-induced diabetic rats. These results suggest that H(2)S exhibits therapeutic potential for diabetes-associated cognitive dysfunction, which is most likely related to its protective effects against hippocampal ER stress. Impact Journals LLC 2017-07-22 /pmc/articles/PMC5609995/ /pubmed/28969063 http://dx.doi.org/10.18632/oncotarget.19448 Text en Copyright: © 2017 Zou et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Zou, Wei
Yuan, Juan
Tang, Zhuo-Jun
Wei, Hai-Jun
Zhu, Wei-Wen
Zhang, Ping
Gu, Hong-Feng
Wang, Chun-Yan
Tang, Xiao-Qing
Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
title Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
title_full Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
title_fullStr Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
title_full_unstemmed Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
title_short Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
title_sort hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609995/
https://www.ncbi.nlm.nih.gov/pubmed/28969063
http://dx.doi.org/10.18632/oncotarget.19448
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