A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and exp...

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Detalles Bibliográficos
Autores principales: Wang, Qixuan, Oh, Ji Won, Lee, Hye-Lim, Dhar, Anukriti, Peng, Tao, Ramos, Raul, Guerrero-Juarez, Christian Fernando, Wang, Xiaojie, Zhao, Ran, Cao, Xiaoling, Le, Jonathan, Fuentes, Melisa A, Jocoy, Shelby C, Rossi, Antoni R, Vu, Brian, Pham, Kim, Wang, Xiaoyang, Mali, Nanda Maya, Park, Jung Min, Choi, June-Hyug, Lee, Hyunsu, Legrand, Julien M D, Kandyba, Eve, Kim, Jung Chul, Kim, Moonkyu, Foley, John, Yu, Zhengquan, Kobielak, Krzysztof, Andersen, Bogi, Khosrotehrani, Kiarash, Nie, Qing, Plikus, Maksim V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610035/
https://www.ncbi.nlm.nih.gov/pubmed/28695824
http://dx.doi.org/10.7554/eLife.22772

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