Mitochondrial mutations drive prostate cancer aggression

Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patient...

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Detalles Bibliográficos
Autores principales: Hopkins, Julia F., Sabelnykova, Veronica Y., Weischenfeldt, Joachim, Simon, Ronald, Aguiar, Jennifer A., Alkallas, Rached, Heisler, Lawrence E., Zhang, Junyan, Watson, John D., Chua, Melvin L. K., Fraser, Michael, Favero, Francesco, Lawerenz, Chris, Plass, Christoph, Sauter, Guido, McPherson, John D., van der Kwast, Theodorus, Korbel, Jan, Schlomm, Thorsten, Bristow, Robert G., Boutros, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610241/
https://www.ncbi.nlm.nih.gov/pubmed/28939825
http://dx.doi.org/10.1038/s41467-017-00377-y

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