Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting

Immunodeficient mice have been used predominantly in biomedical research. Realizing that large animal species may have an enhanced ability to predict clinical outcome relative to mice, we worked to develop immunodeficient rabbits by CRISPR/Cas9. We first demonstrated that multiplex embryo transfer e...

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Detalles Bibliográficos
Autores principales: Song, Jun, Yang, Dongshan, Ruan, Jinxue, Zhang, Jifeng, Chen, Yuqing Eugene, Xu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610260/
https://www.ncbi.nlm.nih.gov/pubmed/28939872
http://dx.doi.org/10.1038/s41598-017-12201-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610260/
https://www.ncbi.nlm.nih.gov/pubmed/28939872
http://dx.doi.org/10.1038/s41598-017-12201-0

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