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Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth

The proliferative and functional heterogeneity among seemingly uniform cells is a universal phenomenon. Identifying the underlying factors requires single-cell analysis of function and proliferation. Here we show that the pancreatic beta-cells in zebrafish exhibit different growth-promoting and func...

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Detalles Bibliográficos
Autores principales:	Singh, Sumeet Pal, Janjuha, Sharan, Hartmann, Theresa, Kayisoglu, Özge, Konantz, Judith, Birke, Sarah, Murawala, Priyanka, Alfar, Ezzaldin Ahmed, Murata, Kei, Eugster, Anne, Tsuji, Naoki, Morrissey, Edward R., Brand, Michael, Ninov, Nikolay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610262/ https://www.ncbi.nlm.nih.gov/pubmed/28939870 http://dx.doi.org/10.1038/s41467-017-00461-3

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