Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD

Non-Alcoholic Fatty Liver Disease (NAFLD) represents the most common form of chronic liver injury and can progress to cirrhosis and hepatocellular carcinoma. A “multi-hit” theory, involving high fat diet and signals from the gut-liver axis, has been hypothesized. The role of the NLRP3-inflammasome,...

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Detalles Bibliográficos
Autores principales: Pierantonelli, Irene, Rychlicki, Chiara, Agostinelli, Laura, Giordano, Debora Maria, Gaggini, Melania, Fraumene, Cristina, Saponaro, Chiara, Manghina, Valeria, Sartini, Loris, Mingarelli, Eleonora, Pinto, Claudio, Buzzigoli, Emma, Trozzi, Luciano, Giordano, Antonio, Marzioni, Marco, Minicis, Samuele De, Uzzau, Sergio, Cinti, Saverio, Gastaldelli, Amalia, Svegliati-Baroni, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610266/
https://www.ncbi.nlm.nih.gov/pubmed/28939830
http://dx.doi.org/10.1038/s41598-017-11744-6

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