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Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development

Recent advancements in the ability to construct three-dimensional (3D) tissues and organoids from stem cells and biomaterials have not only opened abundant new research avenues in disease modeling and regenerative medicine but also have ignited investigation into important aspects of molecular diffu...

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Autor principal: McMurtrey, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610402/
https://www.ncbi.nlm.nih.gov/pubmed/28707964
http://dx.doi.org/10.1089/scd.2017.0066
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author McMurtrey, Richard J.
author_facet McMurtrey, Richard J.
author_sort McMurtrey, Richard J.
collection PubMed
description Recent advancements in the ability to construct three-dimensional (3D) tissues and organoids from stem cells and biomaterials have not only opened abundant new research avenues in disease modeling and regenerative medicine but also have ignited investigation into important aspects of molecular diffusion in 3D cellular architectures. This article describes fundamental mechanics of diffusion with equations for modeling these dynamic processes under a variety of scenarios in 3D cellular tissue constructs. The effects of these diffusion processes and resultant concentration gradients are described in the context of the major molecular signaling pathways in stem cells that both mediate and are influenced by gas and nutrient concentrations, including how diffusion phenomena can affect stem cell state, cell differentiation, and metabolic states of the cell. The application of these diffusion models and pathways is of vital importance for future studies of developmental processes, disease modeling, and tissue regeneration.
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spelling pubmed-56104022017-09-25 Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development McMurtrey, Richard J. Stem Cells Dev Comprehensive Review Recent advancements in the ability to construct three-dimensional (3D) tissues and organoids from stem cells and biomaterials have not only opened abundant new research avenues in disease modeling and regenerative medicine but also have ignited investigation into important aspects of molecular diffusion in 3D cellular architectures. This article describes fundamental mechanics of diffusion with equations for modeling these dynamic processes under a variety of scenarios in 3D cellular tissue constructs. The effects of these diffusion processes and resultant concentration gradients are described in the context of the major molecular signaling pathways in stem cells that both mediate and are influenced by gas and nutrient concentrations, including how diffusion phenomena can affect stem cell state, cell differentiation, and metabolic states of the cell. The application of these diffusion models and pathways is of vital importance for future studies of developmental processes, disease modeling, and tissue regeneration. Mary Ann Liebert, Inc. 2017-09-15 2017-09-15 /pmc/articles/PMC5610402/ /pubmed/28707964 http://dx.doi.org/10.1089/scd.2017.0066 Text en © Richard J. McMurtrey 2017; Published by Mary Ann Liebert, Inc. This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.
spellingShingle Comprehensive Review
McMurtrey, Richard J.
Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development
title Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development
title_full Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development
title_fullStr Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development
title_full_unstemmed Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development
title_short Roles of Diffusion Dynamics in Stem Cell Signaling and Three-Dimensional Tissue Development
title_sort roles of diffusion dynamics in stem cell signaling and three-dimensional tissue development
topic Comprehensive Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610402/
https://www.ncbi.nlm.nih.gov/pubmed/28707964
http://dx.doi.org/10.1089/scd.2017.0066
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