Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes

BACKGROUND: The CD4-induced (CD4i) epitopes in gp120 includes the co-receptor binding site, which are formed and exposed after interaction with CD4. Monoclonal antibodies (mAbs) to the CD4i epitopes exhibit limited neutralizing activity because of restricted access to their epitopes. However, small...

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Detalles Bibliográficos
Autores principales: Tanaka, Kazuki, Kuwata, Takeo, Alam, Muntasir, Kaplan, Gilad, Takahama, Shokichi, Valdez, Kristel Paola Ramirez, Roitburd-Berman, Anna, Gershoni, Jonathan M., Matsushita, Shuzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610415/
https://www.ncbi.nlm.nih.gov/pubmed/28938888
http://dx.doi.org/10.1186/s12977-017-0369-y

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