In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae

Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indic...

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Autores principales: Miari, Victoria F., Solanki, Priya, Hleba, Yonek, Stabler, Richard A., Heap, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610491/
https://www.ncbi.nlm.nih.gov/pubmed/28784667
http://dx.doi.org/10.1128/AAC.00929-17
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author Miari, Victoria F.
Solanki, Priya
Hleba, Yonek
Stabler, Richard A.
Heap, John T.
author_facet Miari, Victoria F.
Solanki, Priya
Hleba, Yonek
Stabler, Richard A.
Heap, John T.
author_sort Miari, Victoria F.
collection PubMed
description Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant N. gonorrhoeae.
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spelling pubmed-56104912017-09-27 In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae Miari, Victoria F. Solanki, Priya Hleba, Yonek Stabler, Richard A. Heap, John T. Antimicrob Agents Chemother Susceptibility Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant N. gonorrhoeae. American Society for Microbiology 2017-09-22 /pmc/articles/PMC5610491/ /pubmed/28784667 http://dx.doi.org/10.1128/AAC.00929-17 Text en Copyright © 2017 Miari et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Susceptibility
Miari, Victoria F.
Solanki, Priya
Hleba, Yonek
Stabler, Richard A.
Heap, John T.
In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae
title In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae
title_full In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae
title_fullStr In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae
title_full_unstemmed In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae
title_short In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae
title_sort in vitro susceptibility to closthioamide among clinical and reference strains of neisseria gonorrhoeae
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610491/
https://www.ncbi.nlm.nih.gov/pubmed/28784667
http://dx.doi.org/10.1128/AAC.00929-17
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