In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis

Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protei...

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Detalles Bibliográficos
Autores principales: McNeil, Matthew B., Dennison, Devon D., Shelton, Catherine D., Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610523/
https://www.ncbi.nlm.nih.gov/pubmed/28760892
http://dx.doi.org/10.1128/AAC.01296-17
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author McNeil, Matthew B.
Dennison, Devon D.
Shelton, Catherine D.
Parish, Tanya
author_facet McNeil, Matthew B.
Dennison, Devon D.
Shelton, Catherine D.
Parish, Tanya
author_sort McNeil, Matthew B.
collection PubMed
description Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA (rrl). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that may limit spread in clinical settings.
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spelling pubmed-56105232017-09-27 In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis McNeil, Matthew B. Dennison, Devon D. Shelton, Catherine D. Parish, Tanya Antimicrob Agents Chemother Mechanisms of Resistance Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA (rrl). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that may limit spread in clinical settings. American Society for Microbiology 2017-09-22 /pmc/articles/PMC5610523/ /pubmed/28760892 http://dx.doi.org/10.1128/AAC.01296-17 Text en Copyright © 2017 McNeil et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
McNeil, Matthew B.
Dennison, Devon D.
Shelton, Catherine D.
Parish, Tanya
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
title In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
title_full In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
title_fullStr In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
title_full_unstemmed In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
title_short In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
title_sort in vitro isolation and characterization of oxazolidinone-resistant mycobacterium tuberculosis
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610523/
https://www.ncbi.nlm.nih.gov/pubmed/28760892
http://dx.doi.org/10.1128/AAC.01296-17
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