Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases

The role of the extracellular matrix (ECM) in uterine fibroids (UF) has recently been appreciated. Overhydroxylation of lysine residues and the subsequent formation of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) cross-links underlie the ECM stiffness and profoundly affect tumor progress...

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Detalles Bibliográficos
Autores principales: Kamel, Marwa, Wagih, Mohamed, Kilic, Gokhan S., Diaz-Arrastia, Concepcion R., Baraka, Mohamed A., Salama, Salama A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610812/
https://www.ncbi.nlm.nih.gov/pubmed/29082249
http://dx.doi.org/10.1155/2017/5316845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610812/
https://www.ncbi.nlm.nih.gov/pubmed/29082249
http://dx.doi.org/10.1155/2017/5316845

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