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Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrare...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610856/ https://www.ncbi.nlm.nih.gov/pubmed/29081820 http://dx.doi.org/10.1155/2017/6376173 |
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author | Paim, Raquel Teixeira Terceiro Benjamin, Stephen Rathinaraj Rondina, Davide Marques, Márcia Maria Mendes Viana, Daniel de Araújo Gonzaga, Maria Leônia da Costa Vieira, Ícaro Gusmão Pinto Mendes, Francisca Noélia Pereira Rodrigues, Paula Alves Salmito Guedes, Maria Izabel Florindo |
author_facet | Paim, Raquel Teixeira Terceiro Benjamin, Stephen Rathinaraj Rondina, Davide Marques, Márcia Maria Mendes Viana, Daniel de Araújo Gonzaga, Maria Leônia da Costa Vieira, Ícaro Gusmão Pinto Mendes, Francisca Noélia Pereira Rodrigues, Paula Alves Salmito Guedes, Maria Izabel Florindo |
author_sort | Paim, Raquel Teixeira Terceiro |
collection | PubMed |
description | The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause. |
format | Online Article Text |
id | pubmed-5610856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56108562017-10-29 Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia Paim, Raquel Teixeira Terceiro Benjamin, Stephen Rathinaraj Rondina, Davide Marques, Márcia Maria Mendes Viana, Daniel de Araújo Gonzaga, Maria Leônia da Costa Vieira, Ícaro Gusmão Pinto Mendes, Francisca Noélia Pereira Rodrigues, Paula Alves Salmito Guedes, Maria Izabel Florindo Evid Based Complement Alternat Med Research Article The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause. Hindawi 2017 2017-06-11 /pmc/articles/PMC5610856/ /pubmed/29081820 http://dx.doi.org/10.1155/2017/6376173 Text en Copyright © 2017 Raquel Teixeira Terceiro Paim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Paim, Raquel Teixeira Terceiro Benjamin, Stephen Rathinaraj Rondina, Davide Marques, Márcia Maria Mendes Viana, Daniel de Araújo Gonzaga, Maria Leônia da Costa Vieira, Ícaro Gusmão Pinto Mendes, Francisca Noélia Pereira Rodrigues, Paula Alves Salmito Guedes, Maria Izabel Florindo Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia |
title | Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia |
title_full | Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia |
title_fullStr | Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia |
title_full_unstemmed | Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia |
title_short | Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia |
title_sort | antihypercholesterolemic effects of fruit aqueous extract of copernicia prunifera (miller) h. e. moore in mice diet-induced hypercholesterolemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610856/ https://www.ncbi.nlm.nih.gov/pubmed/29081820 http://dx.doi.org/10.1155/2017/6376173 |
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