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Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrare...

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Autores principales: Paim, Raquel Teixeira Terceiro, Benjamin, Stephen Rathinaraj, Rondina, Davide, Marques, Márcia Maria Mendes, Viana, Daniel de Araújo, Gonzaga, Maria Leônia da Costa, Vieira, Ícaro Gusmão Pinto, Mendes, Francisca Noélia Pereira, Rodrigues, Paula Alves Salmito, Guedes, Maria Izabel Florindo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610856/
https://www.ncbi.nlm.nih.gov/pubmed/29081820
http://dx.doi.org/10.1155/2017/6376173
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author Paim, Raquel Teixeira Terceiro
Benjamin, Stephen Rathinaraj
Rondina, Davide
Marques, Márcia Maria Mendes
Viana, Daniel de Araújo
Gonzaga, Maria Leônia da Costa
Vieira, Ícaro Gusmão Pinto
Mendes, Francisca Noélia Pereira
Rodrigues, Paula Alves Salmito
Guedes, Maria Izabel Florindo
author_facet Paim, Raquel Teixeira Terceiro
Benjamin, Stephen Rathinaraj
Rondina, Davide
Marques, Márcia Maria Mendes
Viana, Daniel de Araújo
Gonzaga, Maria Leônia da Costa
Vieira, Ícaro Gusmão Pinto
Mendes, Francisca Noélia Pereira
Rodrigues, Paula Alves Salmito
Guedes, Maria Izabel Florindo
author_sort Paim, Raquel Teixeira Terceiro
collection PubMed
description The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.
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spelling pubmed-56108562017-10-29 Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia Paim, Raquel Teixeira Terceiro Benjamin, Stephen Rathinaraj Rondina, Davide Marques, Márcia Maria Mendes Viana, Daniel de Araújo Gonzaga, Maria Leônia da Costa Vieira, Ícaro Gusmão Pinto Mendes, Francisca Noélia Pereira Rodrigues, Paula Alves Salmito Guedes, Maria Izabel Florindo Evid Based Complement Alternat Med Research Article The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause. Hindawi 2017 2017-06-11 /pmc/articles/PMC5610856/ /pubmed/29081820 http://dx.doi.org/10.1155/2017/6376173 Text en Copyright © 2017 Raquel Teixeira Terceiro Paim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Paim, Raquel Teixeira Terceiro
Benjamin, Stephen Rathinaraj
Rondina, Davide
Marques, Márcia Maria Mendes
Viana, Daniel de Araújo
Gonzaga, Maria Leônia da Costa
Vieira, Ícaro Gusmão Pinto
Mendes, Francisca Noélia Pereira
Rodrigues, Paula Alves Salmito
Guedes, Maria Izabel Florindo
Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
title Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
title_full Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
title_fullStr Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
title_full_unstemmed Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
title_short Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
title_sort antihypercholesterolemic effects of fruit aqueous extract of copernicia prunifera (miller) h. e. moore in mice diet-induced hypercholesterolemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610856/
https://www.ncbi.nlm.nih.gov/pubmed/29081820
http://dx.doi.org/10.1155/2017/6376173
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