Synergistic Modulation of Inflammatory but not Metabolic Effects of High-Fat Feeding by CCR2 and CX3CR1

OBJECTIVE: To explore the impact of dual targeting of C-C motif chemokine receptor-2 (CCR2) and fractalkine receptor (CX3CR1) on the metabolic and inflammatory consequences of high fat diet (HFD)-induced obesity. METHODS: C57BL/6J wild type (WT), Cx3cr1(−/−), Ccr2(−/−) and Cx3cr1(−/−)Ccr2(−/−) doubl...

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Detalles Bibliográficos
Autores principales: Zhang, Hanrui, Hinkle, Christine C., O’Neill, Sean M., Shi, Jianting, Caughey, Jennifer, Lynch, Emma, Lynch, Gina, Gerelus, Mark, Tsai, Andrew S. D., Shah, Rachana, Ferguson, Jane F., Ahima, Rexford S., Reilly, Muredach P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610963/
https://www.ncbi.nlm.nih.gov/pubmed/28650582
http://dx.doi.org/10.1002/oby.21900

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