Serotonergic Control of Metabolic Homeostasis

New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This...

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Detalles Bibliográficos
Autores principales: Wyler, Steven C., Lord, Caleb C., Lee, Syann, Elmquist, Joel K., Liu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611374/
https://www.ncbi.nlm.nih.gov/pubmed/28979187
http://dx.doi.org/10.3389/fncel.2017.00277
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author Wyler, Steven C.
Lord, Caleb C.
Lee, Syann
Elmquist, Joel K.
Liu, Chen
author_facet Wyler, Steven C.
Lord, Caleb C.
Lee, Syann
Elmquist, Joel K.
Liu, Chen
author_sort Wyler, Steven C.
collection PubMed
description New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.
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spelling pubmed-56113742017-10-04 Serotonergic Control of Metabolic Homeostasis Wyler, Steven C. Lord, Caleb C. Lee, Syann Elmquist, Joel K. Liu, Chen Front Cell Neurosci Neuroscience New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease. Frontiers Media S.A. 2017-09-20 /pmc/articles/PMC5611374/ /pubmed/28979187 http://dx.doi.org/10.3389/fncel.2017.00277 Text en Copyright © 2017 Wyler, Lord, Lee, Elmquist and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wyler, Steven C.
Lord, Caleb C.
Lee, Syann
Elmquist, Joel K.
Liu, Chen
Serotonergic Control of Metabolic Homeostasis
title Serotonergic Control of Metabolic Homeostasis
title_full Serotonergic Control of Metabolic Homeostasis
title_fullStr Serotonergic Control of Metabolic Homeostasis
title_full_unstemmed Serotonergic Control of Metabolic Homeostasis
title_short Serotonergic Control of Metabolic Homeostasis
title_sort serotonergic control of metabolic homeostasis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611374/
https://www.ncbi.nlm.nih.gov/pubmed/28979187
http://dx.doi.org/10.3389/fncel.2017.00277
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