Peripheral Oxidative Stress Biomarkers in Spinocerebellar Ataxia Type 3/Machado–Joseph Disease

OBJECTIVES: Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a polyglutamine disorder with no current disease-modifying treatment. Conformational changes in mutant ataxin-3 trigger different pathogenic cascades, including reactive oxygen species (ROS) generation; however, the clini...

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Detalles Bibliográficos
Autores principales: de Assis, Adriano M., Saute, Jonas Alex Morales, Longoni, Aline, Haas, Clarissa Branco, Torrez, Vitor Rocco, Brochier, Andressa Wigner, Souza, Gabriele Nunes, Furtado, Gabriel Vasata, Gheno, Tailise Conte, Russo, Aline, Monte, Thais Lampert, Castilhos, Raphael Machado, Schumacher-Schuh, Artur, D’Avila, Rui, Donis, Karina Carvalho, de Mello Rieder, Carlos Roberto, Souza, Diogo Onofre, Camey, Suzi, Leotti, Vanessa Bielefeldt, Jardim, Laura Bannach, Portela, Luis Valmor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611390/
https://www.ncbi.nlm.nih.gov/pubmed/28979235
http://dx.doi.org/10.3389/fneur.2017.00485

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