Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles

Nanoparticles (NPs) containing the photo-therapeutic dye Chlorin e6 (Ce6) have been explored in multiple studies for photo-dynamic therapy (PDT). However, little work has been carried out regarding their PDT efficacy, relative to other dye containing NPs. Here polyacrylamide nanoparticles (PAAm NPs)...

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Detalles Bibliográficos
Autores principales: Hopkins, Thomas, Ukani, Rahil, Kopelman, Raoul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611789/
https://www.ncbi.nlm.nih.gov/pubmed/28956023
http://dx.doi.org/10.16966/2470-3206
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author Hopkins, Thomas
Ukani, Rahil
Kopelman, Raoul
author_facet Hopkins, Thomas
Ukani, Rahil
Kopelman, Raoul
author_sort Hopkins, Thomas
collection PubMed
description Nanoparticles (NPs) containing the photo-therapeutic dye Chlorin e6 (Ce6) have been explored in multiple studies for photo-dynamic therapy (PDT). However, little work has been carried out regarding their PDT efficacy, relative to other dye containing NPs. Here polyacrylamide nanoparticles (PAAm NPs) containing Ce6 were prepared and their PDT efficacy compared to previously reported methylene blue (MB) containing PAAmNPs. It was found that, for identical NP dosages and photon doses, the Ce6 NPs are an order of magnitude more potent in killing cancer cells.
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spelling pubmed-56117892017-09-25 Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles Hopkins, Thomas Ukani, Rahil Kopelman, Raoul Int J Nanomed Nanosurg Article Nanoparticles (NPs) containing the photo-therapeutic dye Chlorin e6 (Ce6) have been explored in multiple studies for photo-dynamic therapy (PDT). However, little work has been carried out regarding their PDT efficacy, relative to other dye containing NPs. Here polyacrylamide nanoparticles (PAAm NPs) containing Ce6 were prepared and their PDT efficacy compared to previously reported methylene blue (MB) containing PAAmNPs. It was found that, for identical NP dosages and photon doses, the Ce6 NPs are an order of magnitude more potent in killing cancer cells. 2016-11-17 2016 /pmc/articles/PMC5611789/ /pubmed/28956023 http://dx.doi.org/10.16966/2470-3206 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Hopkins, Thomas
Ukani, Rahil
Kopelman, Raoul
Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles
title Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles
title_full Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles
title_fullStr Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles
title_full_unstemmed Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles
title_short Intracellular Photodynamic Activity of Chlorin e6 Containing Nanoparticles
title_sort intracellular photodynamic activity of chlorin e6 containing nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611789/
https://www.ncbi.nlm.nih.gov/pubmed/28956023
http://dx.doi.org/10.16966/2470-3206
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