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Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial

Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle i...

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Autores principales: Sindi, Shireen, Ngandu, Tiia, Hovatta, Iiris, Kåreholt, Ingemar, Antikainen, Riitta, Hänninen, Tuomo, Levälahti, Esko, Laatikainen, Tiina, Lindström, Jaana, Paajanen, Teemu, Peltonen, Markku, Khalsa, Dharma Singh, Wolozin, Benjamin, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, Kivipelto, Miia, Solomon, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611796/
https://www.ncbi.nlm.nih.gov/pubmed/28777749
http://dx.doi.org/10.3233/JAD-170123
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author Sindi, Shireen
Ngandu, Tiia
Hovatta, Iiris
Kåreholt, Ingemar
Antikainen, Riitta
Hänninen, Tuomo
Levälahti, Esko
Laatikainen, Tiina
Lindström, Jaana
Paajanen, Teemu
Peltonen, Markku
Khalsa, Dharma Singh
Wolozin, Benjamin
Strandberg, Timo
Tuomilehto, Jaakko
Soininen, Hilkka
Kivipelto, Miia
Solomon, Alina
author_facet Sindi, Shireen
Ngandu, Tiia
Hovatta, Iiris
Kåreholt, Ingemar
Antikainen, Riitta
Hänninen, Tuomo
Levälahti, Esko
Laatikainen, Tiina
Lindström, Jaana
Paajanen, Teemu
Peltonen, Markku
Khalsa, Dharma Singh
Wolozin, Benjamin
Strandberg, Timo
Tuomilehto, Jaakko
Soininen, Hilkka
Kivipelto, Miia
Solomon, Alina
author_sort Sindi, Shireen
collection PubMed
description Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60–77 years identified from the general population. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) and control (general health advice) groups. Primary outcome was change in cognition (comprehensive neuropsychological test battery). Secondary outcomes were changes in cognitive domains: memory, executive functioning, and processing speed. 775 participants (392 control, 383 intervention) had baseline LTL (peripheral blood DNA). Mixed effects regression models with maximum likelihood estimation were used to analyze change in cognition as a function of randomization group, time, baseline LTL, and their interaction. Intervention and control groups did not significantly differ at baseline. Shorter LTL was related to less healthy baseline lifestyle. Intervention benefits on executive functioning were more pronounced among those with shorter baseline LTL (p-value for interaction was 0.010 adjusted for age and sex, and 0.007 additionally adjusted for baseline lifestyle factors). The FINGER intervention cognitive benefits were more pronounced with shorter baseline LTL, particularly for executive functioning, indicating that the multidomain lifestyle intervention was especially beneficial among higher-risk individuals.
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spelling pubmed-56117962017-10-02 Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial Sindi, Shireen Ngandu, Tiia Hovatta, Iiris Kåreholt, Ingemar Antikainen, Riitta Hänninen, Tuomo Levälahti, Esko Laatikainen, Tiina Lindström, Jaana Paajanen, Teemu Peltonen, Markku Khalsa, Dharma Singh Wolozin, Benjamin Strandberg, Timo Tuomilehto, Jaakko Soininen, Hilkka Kivipelto, Miia Solomon, Alina J Alzheimers Dis Research Article Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60–77 years identified from the general population. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) and control (general health advice) groups. Primary outcome was change in cognition (comprehensive neuropsychological test battery). Secondary outcomes were changes in cognitive domains: memory, executive functioning, and processing speed. 775 participants (392 control, 383 intervention) had baseline LTL (peripheral blood DNA). Mixed effects regression models with maximum likelihood estimation were used to analyze change in cognition as a function of randomization group, time, baseline LTL, and their interaction. Intervention and control groups did not significantly differ at baseline. Shorter LTL was related to less healthy baseline lifestyle. Intervention benefits on executive functioning were more pronounced among those with shorter baseline LTL (p-value for interaction was 0.010 adjusted for age and sex, and 0.007 additionally adjusted for baseline lifestyle factors). The FINGER intervention cognitive benefits were more pronounced with shorter baseline LTL, particularly for executive functioning, indicating that the multidomain lifestyle intervention was especially beneficial among higher-risk individuals. IOS Press 2017-08-14 /pmc/articles/PMC5611796/ /pubmed/28777749 http://dx.doi.org/10.3233/JAD-170123 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sindi, Shireen
Ngandu, Tiia
Hovatta, Iiris
Kåreholt, Ingemar
Antikainen, Riitta
Hänninen, Tuomo
Levälahti, Esko
Laatikainen, Tiina
Lindström, Jaana
Paajanen, Teemu
Peltonen, Markku
Khalsa, Dharma Singh
Wolozin, Benjamin
Strandberg, Timo
Tuomilehto, Jaakko
Soininen, Hilkka
Kivipelto, Miia
Solomon, Alina
Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial
title Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial
title_full Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial
title_fullStr Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial
title_full_unstemmed Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial
title_short Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial
title_sort baseline telomere length and effects of a multidomain lifestyle intervention on cognition: the finger randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611796/
https://www.ncbi.nlm.nih.gov/pubmed/28777749
http://dx.doi.org/10.3233/JAD-170123
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