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Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial
BACKGROUND: Although physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia. OBJECTIVES: To investigate effects of exercise on cognitive function in people with dementia. METHOD: The Umeå Dementia and Exercise...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611799/ https://www.ncbi.nlm.nih.gov/pubmed/28800328 http://dx.doi.org/10.3233/JAD-170014 |
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author | Toots, Annika Littbrand, Håkan Boström, Gustaf Hörnsten, Carl Holmberg, Henrik Lundin-Olsson, Lillemor Lindelöf, Nina Nordström, Peter Gustafson, Yngve Rosendahl, Erik |
author_facet | Toots, Annika Littbrand, Håkan Boström, Gustaf Hörnsten, Carl Holmberg, Henrik Lundin-Olsson, Lillemor Lindelöf, Nina Nordström, Peter Gustafson, Yngve Rosendahl, Erik |
author_sort | Toots, Annika |
collection | PubMed |
description | BACKGROUND: Although physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia. OBJECTIVES: To investigate effects of exercise on cognitive function in people with dementia. METHOD: The Umeå Dementia and Exercise (UMDEX) study, a cluster-randomized controlled trial, was set in 16 nursing homes in Umeå, Sweden. One hundred-and-forty-one women and 45 men with dementia; mean age of 85 y and mean Mini-Mental State Examination (MMSE) score of 15, were randomized to a High-Intensity Functional Exercise program or a seated attention control activity. Blinded assessors measured global cognitive function using the MMSE and the Alzheimer’s disease Assessment Scale – Cognitive subscale (ADAS-Cog), and executive function using Verbal fluency (VF) at baseline and 4 months (directly after intervention completion), and MMSE and VF at 7 months. RESULTS: Linear mixed models showed no between-group effects in mean difference from baseline (95% confidence intervals, CI) at 4 months in MMSE (–0.27; 95% CI –1.4 to 0.87, p = 0.644), ADAS-Cog (–1.04, 95% CI –4 to 1.92, p = 0.491), or VF (–0.53, 95% CI –1.42 to 0.35, p = 0.241) or at 7 months in MMSE (–1.15, 95% CI –2.32 to 0.03, p = 0.056) or VF (–0.18, 95% CI –1.09 to 0.74, p = 0.707). CONCLUSION: A 4-month, high-intensity functional exercise program had no superior effects on global cognition or executive function in people with dementia living in nursing homes when compared with an attention control activity. |
format | Online Article Text |
id | pubmed-5611799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56117992017-10-02 Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial Toots, Annika Littbrand, Håkan Boström, Gustaf Hörnsten, Carl Holmberg, Henrik Lundin-Olsson, Lillemor Lindelöf, Nina Nordström, Peter Gustafson, Yngve Rosendahl, Erik J Alzheimers Dis Research Article BACKGROUND: Although physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia. OBJECTIVES: To investigate effects of exercise on cognitive function in people with dementia. METHOD: The Umeå Dementia and Exercise (UMDEX) study, a cluster-randomized controlled trial, was set in 16 nursing homes in Umeå, Sweden. One hundred-and-forty-one women and 45 men with dementia; mean age of 85 y and mean Mini-Mental State Examination (MMSE) score of 15, were randomized to a High-Intensity Functional Exercise program or a seated attention control activity. Blinded assessors measured global cognitive function using the MMSE and the Alzheimer’s disease Assessment Scale – Cognitive subscale (ADAS-Cog), and executive function using Verbal fluency (VF) at baseline and 4 months (directly after intervention completion), and MMSE and VF at 7 months. RESULTS: Linear mixed models showed no between-group effects in mean difference from baseline (95% confidence intervals, CI) at 4 months in MMSE (–0.27; 95% CI –1.4 to 0.87, p = 0.644), ADAS-Cog (–1.04, 95% CI –4 to 1.92, p = 0.491), or VF (–0.53, 95% CI –1.42 to 0.35, p = 0.241) or at 7 months in MMSE (–1.15, 95% CI –2.32 to 0.03, p = 0.056) or VF (–0.18, 95% CI –1.09 to 0.74, p = 0.707). CONCLUSION: A 4-month, high-intensity functional exercise program had no superior effects on global cognition or executive function in people with dementia living in nursing homes when compared with an attention control activity. IOS Press 2017-08-29 /pmc/articles/PMC5611799/ /pubmed/28800328 http://dx.doi.org/10.3233/JAD-170014 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Toots, Annika Littbrand, Håkan Boström, Gustaf Hörnsten, Carl Holmberg, Henrik Lundin-Olsson, Lillemor Lindelöf, Nina Nordström, Peter Gustafson, Yngve Rosendahl, Erik Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial |
title | Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial |
title_full | Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial |
title_fullStr | Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial |
title_full_unstemmed | Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial |
title_short | Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial |
title_sort | effects of exercise on cognitive function in older people with dementia: a randomized controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611799/ https://www.ncbi.nlm.nih.gov/pubmed/28800328 http://dx.doi.org/10.3233/JAD-170014 |
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