Cargando…

Analytical Strategy to Prioritize Alzheimer’s Disease Candidate Genes in Gene Regulatory Networks Using Public Expression Data

Alzheimer’s disease (AD) progressively destroys cognitive abilities in the aging population with tremendous effects on memory. Despite recent progress in understanding the underlying mechanisms, high drug attrition rates have put a question mark behind our knowledge about its etiology. Re-evaluation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kawalia, Shweta Bagewadi, Raschka, Tamara, Naz, Mufassra, de Matos Simoes, Ricardo, Senger, Philipp, Hofmann-Apitius, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611835/ https://www.ncbi.nlm.nih.gov/pubmed/28800327 http://dx.doi.org/10.3233/JAD-170011

Ejemplares similares

NeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's disease
por: Iyappan, Anandhi, et al.
Publicado: (2016)

Systems approach for the selection of micro-RNAs as therapeutic biomarkers of anti-EGFR monoclonal antibody treatment in colorectal cancer
por: Deyati, Avisek, et al.
Publicado: (2015)

Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases
por: Naz, Mufassra, et al.
Publicado: (2016)

Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment
por: Domingo-Fernández, Daniel, et al.
Publicado: (2017)

Linking hypothetical knowledge patterns to disease molecular signatures for biomarker discovery in Alzheimer’s disease
por: Malhotra, Ashutosh, et al.
Publicado: (2014)

Detecting miRNA Mentions and Relations in Biomedical Literature
por: Bagewadi, Shweta, et al.
Publicado: (2015)

NeuroTransDB: highly curated and structured transcriptomic metadata for neurodegenerative diseases
por: Bagewadi, Shweta, et al.
Publicado: (2015)

Candidate gene prioritization with Endeavour
por: Tranchevent, Léon-Charles, et al.
Publicado: (2016)

System-Level Analysis of Alzheimer’s Disease Prioritizes Candidate Genes for Neurodegeneration
por: Brabec, Jeffrey L., et al.
Publicado: (2021)

Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome
por: Lombard, Zané, et al.
Publicado: (2007)

Elucidating gene expression patterns across multiple biological contexts through a large-scale investigation of transcriptomic datasets
por: Figueiredo, Rebeca Queiroz, et al.
Publicado: (2022)

Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimer’s disease brains
por: Gamache, Julia, et al.
Publicado: (2023)

Prioritizing Suggestive Candidate Genes in Migraine: An Opinion
por: Frederiksen, Simona Denise
Publicado: (2022)

Prioritization of candidate cancer genes—an aid to oncogenomic studies
por: Furney, Simon J., et al.
Publicado: (2008)

Conserved co-expression for candidate disease gene prioritization
por: Oti, Martin, et al.
Publicado: (2008)

Prioritization of Epilepsy Associated Candidate Genes by Convergent Analysis
por: Jia, Peilin, et al.
Publicado: (2011)

Integrating human omics data to prioritize candidate genes
por: Chen, Yong, et al.
Publicado: (2013)

A computational framework for the prioritization of disease-gene candidates
por: Browne, Fiona, et al.
Publicado: (2015)

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
por: Chen, Jing, et al.
Publicado: (2009)

Prioritizing disease candidate genes by a gene interconnectedness-based approach
por: Hsu, Chia-Lang, et al.
Publicado: (2011)

Harnessing Gene Expression Networks to Prioritize Candidate Epileptic Encephalopathy Genes
por: Oliver, Karen L., et al.
Publicado: (2014)

Towards a global investigation of transcriptomic signatures through co-expression networks and pathway knowledge for the identification of disease mechanisms
por: Figueiredo, Rebeca Queiroz, et al.
Publicado: (2021)

Gene expression variation in Down's syndrome mice allows prioritization of candidate genes
por: Sultan, Marc, et al.
Publicado: (2007)

Candidate gene prioritization based on spatially mapped gene expression: an application to XLMR
por: Piro, Rosario M., et al.
Publicado: (2010)

Speeding disease gene discovery by sequence based candidate prioritization
por: Adie, Euan A, et al.
Publicado: (2005)

A Methodology to Identify and Prioritize Gene Candidates for Human Disease
por: Sainz, Jesus
Publicado: (2012)

NetworkPrioritizer: a versatile tool for network-based prioritization of candidate disease genes or other molecules
por: Kacprowski, Tim, et al.
Publicado: (2013)

Epigenomic and Transcriptomic Prioritization of Candidate Obesity-Risk Regulatory GWAS SNPs
por: Zhang, Xiao, et al.
Publicado: (2022)

GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles
por: Antanaviciute, Agne, et al.
Publicado: (2015)

Improved human disease candidate gene prioritization using mouse phenotype
por: Chen, Jing, et al.
Publicado: (2007)

Disease candidate gene identification and prioritization using protein interaction networks
por: Chen, Jing, et al.
Publicado: (2009)

Prioritization and Evaluation of Depression Candidate Genes by Combining Multidimensional Data Resources
por: Kao, Chung-Feng, et al.
Publicado: (2011)

Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders
por: Zhang, Yi, et al.
Publicado: (2021)

Harnessing large language models (LLMs) for candidate gene prioritization and selection
por: Toufiq, Mohammed, et al.
Publicado: (2023)

Prioritizing transcriptional factors in gene regulatory networks with PageRank
por: Ding, Hongxu, et al.
Publicado: (2020)

Automatic Gene Prioritization in Support of the Inflammatory Contribution to Alzheimer’s Disease
por: Furniss, Stephanie K, et al.
Publicado: (2014)

PS4DR: a multimodal workflow for identification and prioritization of drugs based on pathway signatures
por: Emon, Mohammad Asif, et al.
Publicado: (2020)

Integration of bioinformatics tools in candidate gene prioritization of co-regulated gene sets in Saccharomyces cerevisiae
por: Abedi, Vida, et al.
Publicado: (2011)

Gene-level Integrated Metric of negative Selection (GIMS) Prioritizes Candidate Genes for Nephrotic Syndrome
por: Sampson, Matthew G., et al.
Publicado: (2013)

Update of the G2D tool for prioritization of gene candidates to inherited diseases
por: Perez-Iratxeta, Carolina, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_6kpruhgasi452dviq3o1uvuvgr