Evidence that the Human Innate Immune Peptide LL-37 may be a Binding Partner of Amyloid-β and Inhibitor of Fibril Assembly

BACKGROUND: Identifying physiologically relevant binding partners of amyloid-β (Aβ) that modulate in vivo fibril formation may yield new insights into Alzheimer’s disease (AD) etiology. Human cathelicidin peptide, LL-37, is an innate immune effector and modulator, ubiquitous in human tissues and exp...

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Detalles Bibliográficos
Autores principales: De Lorenzi, Ersilia, Chiari, Marcella, Colombo, Raffaella, Cretich, Marina, Sola, Laura, Vanna, Renzo, Gagni, Paola, Bisceglia, Federica, Morasso, Carlo, Lin, Jennifer S., Lee, Moonhee, McGeer, Patrick L., Barron, Annelise E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611894/
https://www.ncbi.nlm.nih.gov/pubmed/28731438
http://dx.doi.org/10.3233/JAD-170223

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