p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

Constitutive p16(Ink4a) expression, along with senescence-associated β-galactosidase (SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports attributed improvement of the healthspan of aged mice following p16(Ink4a)-positive cell killing to the eradication of accumulated SC...

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Detalles Bibliográficos
Autores principales: Hall, Brandon M., Balan, Vitaly, Gleiberman, Anatoli S., Strom, Evguenia, Krasnov, Peter, Virtuoso, Lauren P., Rydkina, Elena, Vujcic, Slavoljub, Balan, Karina, Gitlin, Ilya I., Leonova, Katerina I., Consiglio, Camila R., Gollnick, Sandra O., Chernova, Olga B., Gudkov, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611982/
https://www.ncbi.nlm.nih.gov/pubmed/28768895
http://dx.doi.org/10.18632/aging.101268

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