Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-β-catenin axis

Glioblastoma is the most malignant type of brain tumor, and its high invasiveness and multiplication severely shortens patients’ overall survival. The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. We used computational target gene prediction, in vitro cell culture,...

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Detalles Bibliográficos
Autores principales: Han, Bo, Meng, Xiangqi, Chen, Hui, Chen, Lingchao, Liu, Xing, Wang, Hongjun, Liu, Daming, Gao, Fei, Lin, Lin, Ming, Jianguang, Sun, Bo, Yin, Shi, Wang, Ruijia, Wu, Pengfei, Cai, Jinquan, Jiang, Chuanlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611983/
https://www.ncbi.nlm.nih.gov/pubmed/28858851
http://dx.doi.org/10.18632/aging.101271

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