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Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
One of the hallmarks of Alzheimer's disease is the formation of extracellular amyloid plaques that consist mainly of abnormally aggregated forms of amyloid β (Aβ) peptides. These peptides are generated by γ-secretase–catalyzed cleavage of a dimeric membrane-bound C-terminal fragment (C99) of th...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612113/ https://www.ncbi.nlm.nih.gov/pubmed/28790170 http://dx.doi.org/10.1074/jbc.M117.789669 |