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Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

One of the hallmarks of Alzheimer's disease is the formation of extracellular amyloid plaques that consist mainly of abnormally aggregated forms of amyloid β (Aβ) peptides. These peptides are generated by γ-secretase–catalyzed cleavage of a dimeric membrane-bound C-terminal fragment (C99) of th...

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Detalles Bibliográficos
Autores principales:	Yan, Yan, Xu, Ting-Hai, Harikumar, Kaleeckal G., Miller, Laurence J., Melcher, Karsten, Xu, H. Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612113/ https://www.ncbi.nlm.nih.gov/pubmed/28790170 http://dx.doi.org/10.1074/jbc.M117.789669

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