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Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
The integrity of the cellular proteome is supported by quality control networks, which govern protein synthesis, folding, and degradation. It is generally accepted that an age-related decline in protein homeostasis (proteostasis) contributes to protein aggregation diseases. However, the mechanistic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612283/ https://www.ncbi.nlm.nih.gov/pubmed/28959501 http://dx.doi.org/10.1080/21624054.2017.1371403 |