A novel role for SALL4 during scar-free wound healing in axolotl

The human response to serious cutaneous damage is limited to relatively primitive wound healing, whereby collagenous scar tissue fills the wound bed. Scars assure structural integrity at the expense of functional regeneration. In contrast, axolotls have the remarkable capacity to functionally regene...

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Detalles Bibliográficos
Autores principales: Erickson, Jami R, Gearhart, Micah D, Honson, Drew D, Reid, Taylor A, Gardner, Melissa K, Moriarity, Branden S, Echeverri, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612448/
https://www.ncbi.nlm.nih.gov/pubmed/28955504
http://dx.doi.org/10.1038/npjregenmed.2016.16
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author Erickson, Jami R
Gearhart, Micah D
Honson, Drew D
Reid, Taylor A
Gardner, Melissa K
Moriarity, Branden S
Echeverri, Karen
author_facet Erickson, Jami R
Gearhart, Micah D
Honson, Drew D
Reid, Taylor A
Gardner, Melissa K
Moriarity, Branden S
Echeverri, Karen
author_sort Erickson, Jami R
collection PubMed
description The human response to serious cutaneous damage is limited to relatively primitive wound healing, whereby collagenous scar tissue fills the wound bed. Scars assure structural integrity at the expense of functional regeneration. In contrast, axolotls have the remarkable capacity to functionally regenerate full thickness wounds. Here, we identified a novel role for SALL4 in regulating collagen transcription after injury that is essential for perfect skin regeneration in axolotl. Furthermore, we identify miR-219 as a molecular regulator of Sall4 during wound healing. Taken together, our work highlights one molecular mechanism that allows for efficient cutaneous wound healing in the axolotl.
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spelling pubmed-56124482017-09-25 A novel role for SALL4 during scar-free wound healing in axolotl Erickson, Jami R Gearhart, Micah D Honson, Drew D Reid, Taylor A Gardner, Melissa K Moriarity, Branden S Echeverri, Karen NPJ Regen Med Article The human response to serious cutaneous damage is limited to relatively primitive wound healing, whereby collagenous scar tissue fills the wound bed. Scars assure structural integrity at the expense of functional regeneration. In contrast, axolotls have the remarkable capacity to functionally regenerate full thickness wounds. Here, we identified a novel role for SALL4 in regulating collagen transcription after injury that is essential for perfect skin regeneration in axolotl. Furthermore, we identify miR-219 as a molecular regulator of Sall4 during wound healing. Taken together, our work highlights one molecular mechanism that allows for efficient cutaneous wound healing in the axolotl. Nature Publishing Group 2016-12-08 /pmc/articles/PMC5612448/ /pubmed/28955504 http://dx.doi.org/10.1038/npjregenmed.2016.16 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Erickson, Jami R
Gearhart, Micah D
Honson, Drew D
Reid, Taylor A
Gardner, Melissa K
Moriarity, Branden S
Echeverri, Karen
A novel role for SALL4 during scar-free wound healing in axolotl
title A novel role for SALL4 during scar-free wound healing in axolotl
title_full A novel role for SALL4 during scar-free wound healing in axolotl
title_fullStr A novel role for SALL4 during scar-free wound healing in axolotl
title_full_unstemmed A novel role for SALL4 during scar-free wound healing in axolotl
title_short A novel role for SALL4 during scar-free wound healing in axolotl
title_sort novel role for sall4 during scar-free wound healing in axolotl
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612448/
https://www.ncbi.nlm.nih.gov/pubmed/28955504
http://dx.doi.org/10.1038/npjregenmed.2016.16
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