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Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

Lung cancer is the leading cause of cancer-related deaths. Most patients develop resistance to platinum within several months of treatment. We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with a...

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Detalles Bibliográficos
Autores principales:	Circu, Magdalena, Cardelli, James, Barr, Martin, O’Byrne, Kenneth, Mills, Glenn, El-Osta, Hazem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612465/ https://www.ncbi.nlm.nih.gov/pubmed/28945807 http://dx.doi.org/10.1371/journal.pone.0184922

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